Molecular Mechanisms of Drug Resistance in Glioblastoma

被引：81

作者：

Dymova, Maya A. ^{[1
]}

Kuligina, Elena, V ^{[1
]}

Richter, Vladimir A. ^{[1
]}

机构：

[1] Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 12期

基金：

俄罗斯科学基金会;

关键词：

glioblastoma multiforme; drug resistance; molecular mechanism; CANCER STEM-CELLS; BLOOD-BRAIN-BARRIER; TUMOR-ASSOCIATED MACROPHAGES; NEUTRON-CAPTURE THERAPY; CENTRAL-NERVOUS-SYSTEM; INITIATING CELLS; GLIOMA-CELLS; TEMOZOLOMIDE; DELIVERY; IMMUNE;

D O I：

10.3390/ijms22126385

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, is highly resistant to conventional radiation and chemotherapy, and is not amenable to effective surgical resection. The present review summarizes recent advances in our understanding of the molecular mechanisms of therapeutic resistance of GBM to already known drugs, the molecular characteristics of glioblastoma cells, and the barriers in the brain that underlie drug resistance. We also discuss the progress that has been made in the development of new targeted drugs for glioblastoma, as well as advances in drug delivery across the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB).

引用

页数：15

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