Total Synthesis of (-)-4-epi-Englerin A

被引：5

作者：

Kumar Palli, Kishore ^{[1
,2
]}

Reddy Anugu, Raghunath ^{[1
,2
]}

Chandrasekhar, Srivari ^{[1
,2
]}

机构：

[1] CSIR Indian Inst Chem Technol CSIR IICT, Dept Organ Synth & Proc Chem, Hyderabad 500007, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 2021卷 / 22期

关键词：

Chiron approach; Englerin A; Terpenoid; Total synthesis; FORMAL SYNTHESIS; BIOLOGICAL EVALUATION; (-)-ENGLERIN; CYCLOADDITION; ENGLERIN; SESQUITERPENES;

D O I：

10.1002/ejoc.202100354

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of (-)-4-epi-Englerin A, the epimer of natural product (-)-Englerin A, a sesquiterpenoid with exceptional anti-proliferative activity in renal cancer cells is achieved from (R)-(+)-limonene. Key features of the synthesis are Sharpless asymmetric dihydroxylation, aldol reaction, and transannular epoxide opening reactions to install the required functionalities of oxabridged tricyclic core.

引用

页码：3190 / 3196

页数：7

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