Rebalancing metal dyshomeostasis for Alzheimer's disease therapy

被引：30
作者：
Yang, Guan-Jun [1 ]
Liu, Hao [2 ]
Ma, Dik-Lung [2 ]
Leung, Chung-Hang [1 ]
机构：
[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China
[2] Hong Kong Baptist Univ, Dept Chem, Kowloon, Hong Kong 999077, Peoples R China
来源：
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY | 2019年 / 24卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Metal dyshomeostasis; Metal ions; Alzheimer's disease; Metal chelators; A beta aggregation inhibitors; Multifunctional agents; BLOOD-BRAIN-BARRIER; A-BETA AGGREGATION; AMYLOID-BETA; MITOCHONDRIAL DYSFUNCTION; SECONDARY PREVENTION; OXIDATIVE STRESS; ION HOMEOSTASIS; BINDING SITE; COPPER; TAU;
D O I：
10.1007/s00775-019-01712-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alzheimer's disease (AD) is a type of neurodegenerative malady that is associated with the accumulation of amyloid plaques. Metal ions are critical for the development and upkeep of brain activity, but metal dyshomeostasis can contribute to the development of neurodegenerative diseases, including AD. This review highlights the association between metal dyshomeostasis and AD pathology, the feasibility of rebalancing metal homeostasis as a therapeutic strategy for AD, and a survey of current drugs that action via rebalancing metal homeostasis. Finally, we discuss the challenges that should be overcome by researchers in the future to enable the practical use of metal homeostasis rebalancing agents for clinical application.
引用
收藏
页码：1159 / 1170
页数：12
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