Contrasting effects of IFNβ and IVIG in children with central and peripheral demyelination

被引：35
作者：
Pirko, I
Kuntz, NL
Patterson, M
Keegan, BM
Weinshenker, BG
Rodriguez, M
机构：
[1] Mayo Clin, Dept Neurol, Rochester, MN 55902 USA
[2] Mayo Clin, Dept Immunol, Rochester, MN 55902 USA
[3] Columbia Univ, New York, NY USA
来源：
NEUROLOGY | 2003年 / 60卷 / 10期
关键词：
D O I：
10.1212/01.WNL.0000064163.94122.EB
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Reported are three children with MS who responded dramatically to interferon-beta (IFNbeta) therapy. While on immunomodulatory therapy, they developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that responded to IV immunoglobulin (IVIG) administration. These cases emphasize two interesting observations: 1) IFNbeta treatment did not prevent development of CIDP; 2) CIDP in the context of MS responded to IVIG, even though IVIG had no therapeutic effect on the central demyelinating disease.
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页码：1697 / 1699
页数：3
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