Agrocybone, a novel bis-sesquiterpene with a spirodienone structure from basidiomycete Agrocybe salicacola

被引：29

作者：

Zhu, Ying-Cheng ^{[1
,2
]}

Wang, Gang ^{[2
]}

Yang, Xiao-Long ^{[3
]}

Luo, Du-Qiang ^{[3
]}

Zhu, Qin-Chang ^{[4
]}

Peng, Tao ^{[4
]}

Liu, Ji-Kai ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Anhui Coll Tradit Chinese Med, Anhui Key Lab Modernized Chinese Mat Med, Hefei 230031, Peoples R China

[3] Hebei Univ, Key Lab Pharmaceut Chem & Mol Diag, Coll Life Sci, Baoding 71002, Peoples R China

[4] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 26期

基金：

中国国家自然科学基金;

关键词：

EDIBLE MUSHROOM; CYLINDRACEA;

D O I：

10.1016/j.tetlet.2010.04.128

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The isolation, structure elucidation, and relative stereochemistry assignment of a novel illudane-illudane bis-sesquiterpene, agrocybone (1), from the basidiomycete Agrocybe salicacola, were reported. Agrocybone represents a structure with eight rings (including two Spiro rings) and seven stereogenic carbon atoms. Agrocybone was found to exhibit weak antiviral activity against respiratory syncytial virus (RSV) with IC(50) value of 100 mu M. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3443 / 3445

页数：3

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