Matrix stiffness regulates macrophage polarization in atherosclerosis

被引：49

作者：

Wang, Yin ^{[1
]}

Shi, Ruotong ^{[2
]}

Zhai, Ran ^{[2
]}

Yang, Shiyan ^{[2
]}

Peng, Tianqi ^{[2
]}

Zheng, Fuwen ^{[2
]}

Shen, YanNan ^{[3
]}

Li, Meiying ^{[1
]}

Li, Lisha ^{[1
]}

机构：

[1] Jilin Univ, Coll Basic Med Sci, Key Lab Pathobiol, Minist Educ, Changchun 130021, Peoples R China

[2] Jilin Univ, Norman Bethune Coll Med, Changchun 130021, Peoples R China

[3] Jilin Univ, Sch Publ Hlth, NHC Key Lab Radiobiol, Changchun 130021, Peoples R China

来源：

PHARMACOLOGICAL RESEARCH | 2022年 / 179卷

基金：

中国国家自然科学基金;

关键词：

Atherosclerosis; Macrophage polarization; Matrix stiffness; Mechanical signal transduction; Epigenetics; EXTRACELLULAR-MATRIX; DNA METHYLATION; IN-VITRO; SUBSTRATE STIFFNESS; HIPPO PATHWAY; ION-CHANNEL; PLAQUE; CELLS; PROGRESSION; ACTIVATION;

D O I：

10.1016/j.phrs.2022.106236

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Atherosclerosis is a chronic inflammatory disease and the pathological basis of many fatal cardiovascular diseases. Macrophages, the main inflammatory cells in atherosclerotic plaque, have a paradox role in disease progression. In response to different microenvironments, macrophages mainly have two polarized directions: pro-inflammatory macrophages and anti-inflammatory macrophages. More and more evidence shows that macrophage is mechanosensitive and matrix stiffness regulate macrophage phenotypes in atherosclerosis. However, the molecular mechanism of matrix stiffness regulating macrophage polarization still lacks in-depth research, which hinders the development of new anti-atherosclerotic therapies. In this review, we discuss the important role of matrix stiffness in regulating macrophage polarization through mechanical signal transduction (Hippo, Piezo, cytoskeleton, and integrin) and epigenetic mechanisms (miRNA, DNA methylation, and histone). We hope to provide a new perspective for atherosclerosis therapy by targeting matrix stiffness and macrophage polarization.

引用

页数：8

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