Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats

被引：7
|
作者：
Kanazawa, Yuji [1 ,2 ]
Nagano, Mamoru [2 ]
Koinuma, Satoshi [2 ]
Sugiyo, Shinichi [3 ]
Shigeyoshi, Yasufumi [2 ]
机构：
[1] Hokuriku Univ, Dept Med Technol & Clin Engn, Kanazawa, Ishikawa 9201180, Japan
[2] Kindai Univ, Grad Sch Med Sci, Dept Anat & Neurobiol, Ohnohigashi, Osakasayama 5898511, Japan
[3] Osaka Univ Human Sci, Dept Phys Therapy, Shojya Ku, Settsu 5668501, Japan
来源：
MICROSCOPY | 2022年 / 71卷 / 04期
关键词：
muscle injury; aging; basement membrane; skeletal muscle; collagen IV; recovery; SKELETAL-MUSCLE; COLLAGEN; REGENERATION; MYOTOXICITY; MUTATIONS; COL4A1;
D O I：
10.1093/jmicro/dfac016
中图分类号：
TH742 [显微镜];
学科分类号：
摘要：
We investigated the effect of aging on the basement membrane (BM) during postinjury muscle recovery. Using a rat model, we found that aging delayed muscle fiber and BM recovery. In addition, expression of BM-related factors peaked 7 days after muscle injury among both young and older rats. Peak expression of collagen IV synthetic factors decreased with age, whereas expression of the degradative factor was unaffected by age. These results suggest that age-related delays in postinjury muscle fiber and BM recovery may be related to the suppression of collagen IV synthetic factors.
引用
收藏
页码：245 / 248
页数：4
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