Synthesis and Anti-tumor Study of 3-Aryl-4-oxo-thiazolidin-2-carboxylic Acid Amides

被引：0

作者：

Chen, Hua ^{[1
]}

Yuan, Xiangguo ^{[1
]}

Qin, Zhanbin ^{[1
]}

Zhao, Jianpeng ^{[1
]}

Li, Xiaoliu ^{[1
]}

Zhang, Jinchao ^{[1
]}

机构：

[1] Hebei Univ, Key Lab Chem Biol Hebei Prov, Key Lab Med Chem & Mol Diag, Minist Educ,Coll Chem & Environm Sci, Baoding 071002, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 30卷 / 04期

关键词：

thiazolidin-4-one; synthesis; cytotoxic activity; tumor cell; structure-activity relationship; MICROWAVE-ASSISTED SYNTHESIS; CYTOTOXIC AGENTS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel 3-aryl-4-oxo-thiazolidin-2-carboxylic acid amides were synthesized and evaluated for their antiproliferative activity for three tumor cells. Some compounds showed weak cytotoxicity against A-549 and Hela tumor cells, but no antiproliferative activity against BGC-823, which suggested such compounds with a certain cytotoxicity selectivity to the three tumor cells. Among them, compound 7ad was the best one against A-549 with the 1050 value of 21.0 mu mol.L-1, nearly equivalent to that of the positive control cisplatin (IC50=19.4 mu mol.L-1). Preliminary structure activity relationship analysis of these analogues suggested that the steric factor may be important to the anti-tumor activity.

引用

页码：611 / 616

页数：6

共 12 条

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