Conformational isomerism in the solid-state structures of tetracaine and tamoxifen with para-sulphonato-calix[4]arene

被引：12

作者：

Danylyuk, Oksana ^{[1
]}

Monachino, Melaby ^{[2
]}

Lazar, Adina N. ^{[2
]}

Suwinska, Kinga ^{[1
]}

Coleman, Anthony W. ^{[2
]}

机构：

[1] Polish Acad Sci, Inst Phys Chem, PL-01224 Warsaw, Poland

[2] Univ Lyon 1, CNRS, UMR 5086, Inst Biol & Chim Prot, F-69367 Lyon, France

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2010年 / 965卷 / 1-3期

关键词：

Calix[4]arene; Drug; Crystal structure; Tamoxifen; Tetracaine; SOLUBILIZATION; COMPLEXES; HYDROCHLORIDE; CYCLODEXTRINS; DERIVATIVES; BILAYER; CATIONS;

D O I：

10.1016/j.molstruc.2009.11.051

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The solid-state complexes between para-sulphonato-calix[4]arene and the drugs tamoxifen and tetracaine show an unusual 4:1 guest-host stoichiometry with formation of hydrophobic layer of drug molecules held between bilayers of para-sulphonato-calix[4]arene. In both structures each of the four independent drug molecules adopts different conformation due to the different mode of interaction with the anionic host, the neighbouring drug cations and water molecules. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：116 / 120

页数：5

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