Different pattern of association of paraoxonase Gln192→Arg polymorphism with sporadic late-onset Alzheimer's disease and coronary artery disease

被引：34
|
作者：
Scacchi, R
Gambina, G
Martini, MC
Broggio, E
Vilardo, T
Corbo, RM
机构：
[1] Univ Roma La Sapienza, CNR, Ctr Evolutionary Genet, Dept Genet & Mol Biol, I-00185 Rome, Italy
[2] Hosp Verona, Div Neurol, Verona, Italy
[3] S Giovanni Hosp, Rome, Italy
来源：
NEUROSCIENCE LETTERS | 2003年 / 339卷 / 01期
关键词：
Alzheimer's disease; coronary artery disease; DNA polymorphisms; paraoxonase;
D O I：
10.1016/S0304-3940(02)01437-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The paraoxonase (PON1) Gln192 --> Arg polymorphism was examined in a group of sporadic late-onset Alzheimer's disease (AD) patients, in a group of coronary artery disease (CAD) patients, and in normal subjects. The AD sample showed a PON1 *R allele frequency significantly lower than the control group (0.225 vs. 0.281, P = 0.049). In the CAD patients the *R allele was more frequent than in the controls (0.230 vs. 0.213), though not significantly (P = 0.28). The odds ratios (OR) adjusted for age, gender, and APOE polymorphism by logistic regression analysis highlighted that in AD the PON1 RR genotype was significantly protective (OR = 0.41, 95% CI = 0.19-0.90; P = 0.025), whereas in CAD it appeared to be a significant risk factor (OR = 5.11, 95% CI = 1.09-23.9; P = 0.038) limited to younger patients. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：17 / 20
页数：4
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