Mechanisms of oestrogen receptor (ER) gene regulation in breast cancer

被引：67

作者：

Carroll, J. S. ^{[1
]}

机构：

[1] Univ Cambridge, Cambridge Inst, Canc Res UK, Cambridge, England

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2016年 / 175卷 / 01期

关键词：

RANDOMIZED CLINICAL-TRIAL; MEGESTROL-ACETATE; ANDROGEN RECEPTOR; ENDOCRINE RESISTANCE; MOLECULAR PORTRAITS; PS2; GENE; TRANSCRIPTION; ALPHA; BINDING; CHROMATIN;

D O I：

10.1530/EJE-16-0124

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Most breast cancers are driven by a transcription factor called oestrogen receptor ( ER). Understanding the mechanisms of ER activity in breast cancer has been a major research interest and recent genomic advances have revealed extraordinary insights into how ER mediates gene transcription and what occurs during endocrine resistance. This review discusses our current understanding on ER activity, with an emphasis on several evolving, but important areas of ER biology.

引用

页码：R41 / R49

页数：9

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