p38 MAPKs - roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets

被引：59

作者：

Brennan, Christopher M. ^{[1
]}

Emerson, Charles P., Jr. ^{[2
]}

Owens, Jane ^{[1
]}

Christoforou, Nicolas ^{[1
]}

机构：

[1] Pfizer Inc, Rare Dis Res Unit, Cambridge, MA 02139 USA

[2] Univ Massachusetts, Sch Med, Dept Neurol, Wellstone Muscular Dystrophy Program, Worcester, MA USA

来源：

JCI INSIGHT | 2021年 / 6卷 / 12期

关键词：

ACTIVATED PROTEIN-KINASE; FACIOSCAPULOHUMERAL MUSCULAR-DYSTROPHY; LAMIN A/C GENE; SATELLITE CELL ACTIVATION; DILATED CARDIOMYOPATHY; TRANSCRIPTION FACTORS; P38-ALPHA MAPK; OXIDATIVE STRESS; DUX4; EXPRESSION; SELF-RENEWAL;

D O I：

10.1172/jci.insight.149915

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

p38 MAPKs play a central role in orchestrating the cellular response to stress and inflammation and in the regulation of myogenesis. Potent inhibitors of p38 MAPKs have been pursued as potential therapies for several disease indications due to their antiinflammatory properties, although none have been approved to date. Here, we provide a brief overview of p38 MAPKs, including their role in regulating myogenesis and their association with disease progression. Finally, we discuss targeting p38 MAPKs as a therapeutic approach for treating facioscapulohumeral muscular dystrophy and other muscular dystrophies by addressing multiple pathological mechanisms in skeletal muscle.

引用

页数：10

共 113 条

[1] Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation [J].

Ansseau, Eugenie ;

Eidahl, Jocelyn O. ;

Lancelot, Celine ;

Tassin, Alexandra ;

Matteotti, Christel ;

Yip, Cassandre ;

Liu, Jian ;

Leroy, Baptiste ;

Hubeau, Celine ;

Gerbaux, Cecile ;

Cloet, Samuel ;

Wauters, Armelle ;

Zorbo, Sabrina ;

Meyer, Pierre ;

Pirson, Isabelle ;

Laoudj-Chenivesse, Dalila ;

Wattiez, Ruddy ;

Harper, Scott Q. ;

Belayew, Alexandra ;

Coppee, Frederique .

PLOS ONE, 2016, 11 (01)

[2] Skeletal muscle regeneration in facioscapulohumeral muscular dystrophy is correlated with pathological severity [J].

Banerji, Christopher R. S. ;

Henderson, Don ;

Tawil, Rabi N. ;

Zammit, Peter S. .

HUMAN MOLECULAR GENETICS, 2020, 29 (16) :2746-2760

[3] MyoD and the transcriptional control of myogenesis [J].

Berkes, CA ;

Tapscott, SJ .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2005, 16 (4-5) :585-595

[4] Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy [J].

Bonne, G ;

Di Barletta, MR ;

Varnous, S ;

Bécane, HM ;

Hammouda, EH ;

Merlini, L ;

Muntoni, F ;

Greenberg, CR ;

Gary, F ;

Urtizberea, JA ;

Duboc, D ;

Fardeau, M ;

Toniolo, D ;

Schwartz, K .

NATURE GENETICS, 1999, 21 (03) :285-288

[5] An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies [J].

Bosnakovski, Darko ;

Xu, Zhaohui ;

Gang, Eun Ji ;

Galindo, Cristi L. ;

Liu, Mingju ;

Simsek, Tugba ;

Garner, Harold R. ;

Agha-Mohammadi, Siamak ;

Tassin, Alexandra ;

Coppee, Frederique ;

Belayew, Alexandra ;

Perlingeiro, Rita R. ;

Kyba, Michael .

EMBO JOURNAL, 2008, 27 (20) :2766-2779

[6] The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain [J].

Bosnakovski, Darko ;

Toso, Erik A. ;

Hartweck, Lynn M. ;

Magli, Alessandro ;

Lee, Heather A. ;

Thompson, Eliza R. ;

Dandapat, Abhijit ;

Perlingeiro, Rita C. R. ;

Kyba, Michael .

JOURNAL OF CELL SCIENCE, 2017, 130 (21) :3685-3697

[7] p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts [J].

Briata, P ;

Forcales, SV ;

Ponassi, M ;

Corte, G ;

Chen, CY ;

Karin, M ;

Puri, PL ;

Gherzi, R .

MOLECULAR CELL, 2005, 20 (06) :891-903

[8] Lamin A/C gene mutation associated with dilated cardiomyopathy with variable skeletal muscle involvement [J].

Brodsky, GL ;

Muntoni, F ;

Miocic, S ;

Sinagra, G ;

Sewry, C ;

Mestroni, L .

CIRCULATION, 2000, 101 (05) :473-476

[9] PAX3 and PAX7 as upstream regulators of myogenesis [J].

Buckingham, Margaret ;

Relaix, Frederic .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2015, 44 :115-125

[10] Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation [J].

Bulavin, DV ;

Saito, S ;

Hollander, MC ;

Sakaguchi, K ;

Anderson, CW ;

Appella, E ;

Fornace, AJ .

EMBO JOURNAL, 1999, 18 (23) :6845-6854

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