Oxidation of Glutathione by [FeIV(O)(N4Py)]2+: Characterization of an [FeIII(SG)(N4Py)]2+ Intermediate

被引：17

作者：

Campanali, Ashley A. ^{[1
]}

Kwiecien, Timothy D. ^{[1
]}

Hryhorczuk, Lew ^{[1
]}

Kodanko, Jeremy J. ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

INORGANIC CHEMISTRY | 2010年 / 49卷 / 11期

关键词：

NONHEME OXOIRON(IV) COMPLEX; MYOGLOBIN; CYTOCHROME-P-450; REACTIVITY; CHEMISTRY; LIGANDS; ENZYMES; MODELS; REDOX;

D O I：

10.1021/ic100439n

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The mechanism of glutathione (GSH) oxidation by a nonheme ferryl species has been investigated. The reaction of [Fe-IV(O)(N4Py)](2+) (1) with GSH in an aqueous solution leads to the rapid formation of a green intermediate, characterized as the low-spin ferric complex [Fe-III(SG)(N4Py)](2+) (2) by UV-vis and electron paramagnetic resonance spectroscopies and by high-resolution time-of-flight mass spectrometry. Intermediate 2 decays to form the final products [Fe-II(OH2)(N4Py)](2+) and the disulfide GSSG over time. The overall reaction was fit to a three-step process involving rapid quenching of the ferryl by GSH, followed by the formation and decay of 2, which are both second-order processes.

引用

页码：4759 / 4761

页数：3

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