A comprehensive catalogue of somatic mutations in cancer genomes

被引：4

作者：

Friedberg, Errol C. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Lab Mol Pathol, Dept Pathol, Dallas, TX 75390 USA

来源：

DNA REPAIR | 2010年 / 9卷 / 04期

关键词：

Somatic mutations; Cancer genomes;

D O I：

10.1016/j.dnarep.2010.01.013

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This Hot Topics contribution considers two recently published papers that demonstrate the utility of advanced DNA sequencing technologies for identifying classes of mutations other than base substitutions. Data are presented from genome analyses of immortalized cell lines derived from a malignant melanoma and a small cell carcinoma of the lung. Among other observations the studies suggest the operation of novel DNA repair mechanisms or modes. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：468 / 469

页数：2

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