Clinical Applications of Liquid Biopsy in Non-Small Cell Lung Cancer Patients: Current Status and Recent Advances in Clinical Practice

被引：5

作者：

Park, Shinhee ^{[1
]}

Lee, Jae-Cheol ^{[2
]}

Choi, Chang-Min ^{[2
,3
]}

机构：

[1] Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Div Allergy & Resp Med, Bucheon 14584, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul 05505, South Korea

[3] Univ Ulsan, Coll tMed, Asan Med Ctr, Dept Pulm & Crit Care Med, Seoul 05505, South Korea

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 11期

关键词：

lung cancer; liquid biopsy; non-small cell lung carcinoma; CIRCULATING TUMOR DNA; FREE NUCLEIC-ACIDS; RESISTANCE MUTATIONS; ACQUIRED-RESISTANCE; KRAS MUTATIONS; BLOOD-PLASMA; NSCLC; CRIZOTINIB; GEFITINIB; SERUM;

D O I：

10.3390/jcm10112236

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent advances in targeted and immune therapies have enabled tailored treatment strategies for advanced lung cancer. Identifying and understanding the genomic alterations that arise in the course of tumor evolution has become hugely valuable, but tissue biopsies are often insufficient for representing the whole cancer genome due to tumor heterogeneity. A liquid biopsy refers to the isolation and analysis of any tumor-derived material in the blood, and recent studies of this material have mostly focused on cell-free tumor DNA (ctDNA) in plasma. Indeed, liquid biopsy analysis is now expected to expand in utility and scope in clinical practice. In this review, we assess the biology and technical aspects of ctDNA analysis and discuss how it is currently applied in the clinic. Key points: Liquid biopsy is a potentially powerful tool in the era of personalized medicine for guiding targeted therapies in non-small cell lung cancer.

引用

页数：11

共 77 条

[1] Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
Abbosh, Christopher
Birkbak, Nicolai J.
Wilson, Gareth A.
Jamal-Hanjani, Mariam
Constantin, Tudor
Salari, Raheleh
Le Quesne, John
Moore, David A.
Veeriah, Selvaraju
Rosenthal, Rachel
Marafioti, Teresa
Kirkizlar, Eser
Watkins, Thomas B. K.
McGranahan, Nicholas
Ward, Sophia
Martinson, Luke
Riley, Joan
Fraioli, Francesco
Al Bakir, Maise
Gronroos, Eva
Zambrana, Francisco
Endozo, Raymondo
Bi, Wenya Linda
Fennessy, Fiona M.
Sponer, Nicole
Johnson, Diana
Laycock, Joanne
Shafi, Seema
Czyzewska-Khan, Justyna
Rowan, Andrew
Chambers, Tim
Matthews, Nik
Turajlic, Samra
Hiley, Crispin
Lee, Siow Ming
Forster, Martin D.
Ahmad, Tanya
Falzon, Mary
Borg, Elaine
Lawrence, David
Hayward, Martin
Kolvekar, Shyam
Panagiotopoulos, Nikolaos
Janes, Sam M.
Thakrar, Ricky
Ahmed, Asia
Blackhall, Fiona
Summers, Yvonne
Hafez, Dina
Naik, Ashwini
[J]. NATURE, 2017, 545 (7655) : 446 - +
[2] Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening
Aberle, Denise R.
Adams, Amanda M.
Berg, Christine D.
Black, William C.
Clapp, Jonathan D.
Fagerstrom, Richard M.
Gareen, Ilana F.
Gatsonis, Constantine
Marcus, Pamela M.
Sicks, JoRean D.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (05) : 395 - 409
[3] Dynamics of Tumor and Immune Responses during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer
Anagnostou, Valsamo
Forde, Patrick M.
White, James R.
Niknafs, Noushin
Hruban, Carolyn
Naidoo, Jarushka
Marrone, Kristen
Sivakumar, I. K. Ashok
Bruhm, Daniel C.
Rosner, Samuel
Phallen, Jillian
Leal, Alessandro
Adleff, Vilmos
Smith, Kellie N.
Cottrell, Tricia R.
Rhymee, Lamia
Palsgrove, Doreen N.
Hann, Christine L.
Levy, Benjamin
Feliciano, Josephine
Georgiades, Christos
Verde, Franco
Illei, Peter
Li, Qing Kay
Gabrielson, Edward
Brock, Malcolm V.
Isbell, James M.
Sauter, Jennifer L.
Taube, Janis
Scharpf, Robert B.
Karchin, Rachel
Pardoll, Drew M.
Chaft, Jamie E.
Hellmann, Matthew D.
Brahmer, Julie R.
Velculescu, Victor E.
[J]. CANCER RESEARCH, 2019, 79 (06) : 1214 - 1225
[4] Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Bettegowda, Chetan
Sausen, Mark
Leary, Rebecca J.
Kinde, Isaac
Wang, Yuxuan
Agrawal, Nishant
Bartlett, Bjarne R.
Wang, Hao
Luber, Brandon
Alani, Rhoda M.
Antonarakis, Emmanuel S.
Azad, Nilofer S.
Bardelli, Alberto
Brem, Henry
Cameron, John L.
Lee, Clarence C.
Fecher, Leslie A.
Gallia, Gary L.
Gibbs, Peter
Le, Dung
Giuntoli, Robert L.
Goggins, Michael
Hogarty, Michael D.
Holdhoff, Matthias
Hong, Seung-Mo
Jiao, Yuchen
Juhl, Hartmut H.
Kim, Jenny J.
Siravegna, Giulia
Laheru, Daniel A.
Lauricella, Calogero
Lim, Michael
Lipson, Evan J.
Marie, Suely Kazue Nagahashi
Netto, George J.
Oliner, Kelly S.
Olivi, Alessandro
Olsson, Louise
Riggins, Gregory J.
Sartore-Bianchi, Andrea
Schmidt, Kerstin
Shih, Ie-Ming
Oba-Shinjo, Sueli Mieko
Siena, Salvatore
Theodorescu, Dan
Tie, Jeanne
Harkins, Timothy T.
Veronese, Silvio
Wang, Tian-Li
Weingart, Jon D.
[J]. SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (224)
[5] Detection of ALK and KRAS Mutations in Circulating Tumor DNA of Patients With Advanced ALK-Positive NSCLC With Disease Progression During Crizotinib Treatment
Bordi, Paola
Tiseo, Marcello
Rofi, Eleonora
Petrini, Iacopo
Restante, Giuliana
Danesi, Romano
Del Re, Marzia
[J]. CLINICAL LUNG CANCER, 2017, 18 (06) : 692 - 697
[6] Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab
Bratman, Scott V.
Yang, S. Y. Cindy
Iafolla, Marco A. J.
Liu, Zhihui
Hansen, Aaron R.
Bedard, Philippe L.
Lheureux, Stephanie
Spreafico, Anna
Razak, Albiruni Abdul
Shchegrova, Svetlana
Louie, Maggie
Billings, Paul
Zimmermann, Bernhard
Sethi, Himanshu
Aleshin, Alexey
Torti, Dax
Marsh, Kayla
Eagles, Jenna
Cirlan, Iulia
Hanna, Youstina
Clouthier, Derek L.
Lien, Scott C.
Ohashi, Pamela S.
Xu, Wei
Siu, Lillian L.
Pugh, Trevor J.
[J]. NATURE CANCER, 2020, 1 (09) : 873 - +
[7] Clinical potential of circulating tumour DNA in patients receiving anticancer immunotherapy
Cabel, Luc
Proudhon, Charlotte
Romano, Emanuela
Girard, Nicolas
Lantz, Olivier
Stern, Marc-Henri
Pierga, Jean-Yves
Bidard, Francois-Clement
[J]. NATURE REVIEWS CLINICAL ONCOLOGY, 2018, 15 (10) : 639 - 650
[8] Clinical application of amplicon-based next-generation sequencing in cancer
Chang, Fengqi
Li, Marilyn M.
[J]. CANCER GENETICS, 2013, 206 (12) : 413 - 419
[9] Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling
Chaudhuri, Aadel A.
Chabon, Jacob J.
Lovejoy, Alexander F.
Newman, Aaron M.
Stehr, Henning
Azad, Tej D.
Khodadoust, Michael S.
Esfahani, Mohammad Shahrokh
Liu, Chih Long
Zhou, Li
Scherer, Florian
Kurtz, David M.
Say, Carmen
Carter, Justin N.
Merriott, David J.
Dudley, Jonathan C.
Binkley, Michael S.
Modlin, Leslie
Padda, Sukhmani K.
Gensheimer, Michael F.
West, Robert B.
Shrager, Joseph B.
Neal, Joel W.
Wakelee, Heather A.
Loo, Billy W., Jr.
Alizadeh, Ash A.
Diehn, Maximilian
[J]. CANCER DISCOVERY, 2017, 7 (12) : 1394 - 1403
[10] Comparison of plasma to tissue DNA mutations in surgical patients with non-small cell lung cancer Discussion
Schrump, D.
Chen, Kezhong
[J]. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2017, 154 (03) : 1130 - +

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