Management of glioblastoma in elderly patients

被引：36

作者：

Young, Jacob S. ^{[1
]}

Chmura, Steven J. ^{[2
]}

Wainwright, Derek A. ^{[3
]}

Yamini, Bakhtiar ^{[4
]}

Peters, Katherine B. ^{[5
]}

Lukas, Rimas V. ^{[6
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA USA

[2] Univ Chicago, Dept Radiat & Cellular Oncol, Chicago, IL 60637 USA

[3] Northwestern Univ, Dept Neurosurg, Chicago, IL 60611 USA

[4] Univ Chicago, Sect Neurosurg, Chicago, IL 60637 USA

[5] Duke Univ, Dept Neurol, Durham, NC 27706 USA

[6] Northwestern Univ, Dept Neurol, Chicago, IL 60611 USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2017年 / 380卷

关键词：

Glioblastoma; High-grade glioma; Elderly; Surgical resection; Chemotherapy; Radiation therapy; Geriatric; NEWLY-DIAGNOSED GLIOBLASTOMA; RECURSIVE PARTITIONING ANALYSIS; SINGLE-AGENT BEVACIZUMAB; GROSS-TOTAL RESECTION; RANDOMIZED PHASE-III; RECURRENT GLIOBLASTOMA; RADIATION-THERAPY; OLDER PATIENTS; ONCOLOGICAL PATTERNS; PROGNOSTIC-FACTORS;

D O I：

10.1016/j.jns.2017.07.048

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults over 55 years of age. The median age of diagnosis for patients with GBM is 64 years old, with the incidence of patients between 75 and 85 increasing. The optimal treatment paradigm for elderly GBM patients continues to evolve due to the higher frequency of age-related and/or medical co-morbidities. Geriatric GBM patients have historically been excluded from larger, controlled clinical trials due to their presumed decreased likelihood of a sustained treatment response and/or a prolonged good outcome. Here, we highlight current treatment considerations of elderly GBM patients with respect to surgical, radiotherapeutic and systemic modalities, with considerations for improving future clinical outcomes for this patient population. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：250 / 255

页数：6

共 66 条

[41] Deferred use of bevacizumab for recurrent glioblastoma is not associated with diminished efficacy [J].

Piccioni, David E. ;

Selfridge, Julia ;

Mody, Reema R. ;

Chowdhury, Reshmi ;

Li, Sichen ;

Lalezari, Shadi ;

Wawrzynski, James ;

Quan, Jennifer ;

Zurayk, Mira ;

Chou, Arthur P. ;

Sanchez, Desiree E. ;

Liau, Linda M. ;

Ellingson, Benjamin M. ;

Pope, Whitney B. ;

Nghiemphu, Phioanh L. ;

Green, Richard M. ;

Wang, He-jing ;

Yong, William H. ;

Elashoff, Robert ;

Cloughesy, Timothy F. ;

Lai, Albert .

NEURO-ONCOLOGY, 2014, 16 (06) :815-822

[42] Experiences with reoperation on recurrent glioblastoma multiforme [J].

Pinsker, M ;

Lumenta, C .

ZENTRALBLATT FUR NEUROCHIRURGIE, 2001, 62 (02) :43-47

[43] IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group [J].

Pollack, Ian F. ;

Hamilton, Ronald L. ;

Sobol, Robert W. ;

Nikiforova, Marina N. ;

Lyons-Weiler, Maureen A. ;

LaFramboise, William A. ;

Burger, Peter C. ;

Brat, Daniel J. ;

Rosenblum, Marc K. ;

Holmes, Emiko J. ;

Zhou, Tianni ;

Jakacki, Regina I. .

CHILDS NERVOUS SYSTEM, 2011, 27 (01) :87-94

[44] Benefit of tumor resection for recurrent glioblastoma [J].

Quick, Johanna ;

Gessler, Florian ;

Duetzmann, Stephan ;

Hattingen, Elke ;

Harter, Patrick N. ;

Weise, Lutz M. ;

Franz, Kea ;

Seifert, Volker ;

Senft, Christian .

JOURNAL OF NEURO-ONCOLOGY, 2014, 117 (02) :365-372

[45] Predictive impact of MGMT promoter methylation in glioblastoma of the elderly [J].

Reifenberger, Guido ;

Hentschel, Bettina ;

Felsberg, Joerg ;

Schackert, Gabriele ;

Simon, Matthias ;

Schnell, Oliver ;

Westphal, Manfred ;

Wick, Wolfgang ;

Pietsch, Torsten ;

Loeffler, Markus ;

Weller, Michael .

INTERNATIONAL JOURNAL OF CANCER, 2012, 131 (06) :1342-1350

[46] Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection [J].

Ringel, Florian ;

Pape, Haiko ;

Sabel, Michael ;

Krex, Dietmar ;

Bock, Hans Christoph ;

Misch, Martin ;

Weyerbrock, Astrid ;

Westermaier, Thomas ;

Senft, Christian ;

Schucht, Philippe ;

Meyer, Bernhard ;

Simon, Matthias .

NEURO-ONCOLOGY, 2016, 18 (01) :96-104

[47] Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: A prospective randomized clinical trial [J].

Roa, W ;

Brasher, PMA ;

Bauman, G ;

Anthes, M ;

Bruera, E ;

Chan, A ;

Fisher, B ;

Fulton, D ;

Gulavita, S ;

Hao, C ;

Husain, S ;

Murtha, A ;

Petruk, K ;

Stewart, D ;

Tai, P ;

Urtasun, R ;

Cairncross, JG ;

Forsyth, P .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (09) :1583-1588

[48] International Atomic Energy Agency Randomized Phase III Study of Radiation Therapy in Elderly and/or Frail Patients With Newly Diagnosed Glioblastoma Multiforme [J].

Roa, Wilson ;

Kepka, Lucyna ;

Kumar, Narendra ;

Sinaika, Valery ;

Matiello, Juliana ;

Lomidze, Darejan ;

Hentati, Dalenda ;

de Castro, Douglas Guedes ;

Dyttus-Cebulok, Katarzyna ;

Drodge, Suzanne ;

Ghosh, Sunita ;

Jeremic, Branislav ;

Rosenblatt, Eduardo ;

Fidarova, Elena .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (35) :4145-+

[49] Recursive Partitioning Analysis of Prognostic Factors for Glioblastoma Patients Aged 70 Years or Older [J].

Scott, Jacob G. ;

Bauchet, Luc ;

Fraum, Tyler J. ;

Nayak, Lakshmi ;

Cooper, Anna R. ;

Chao, Samuel T. ;

Suh, John H. ;

Vogelbaum, Michael A. ;

Peereboom, David M. ;

Zouaoui, Sonia ;

Mathieu-Daude, Helene ;

Fabbro-Peray, Pascale ;

Rigau, Valerie ;

Taillandier, Luc ;

Abrey, Lauren E. ;

DeAngelis, Lisa M. ;

Shih, Joanna H. ;

Iwamoto, Fabio M. .

CANCER, 2012, 118 (22) :5595-5600

[50] Outcome of treatment of recurrent glioblastoma multiforme in elderly and/or frail patients [J].

Socha, Joanna ;