RNA epigenetics

被引：92
作者：
Liu, Nian
Pan, Tao
机构：
[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA
[3] Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USA
来源：
TRANSLATIONAL RESEARCH | 2015年 / 165卷 / 01期
基金：
美国国家卫生研究院;
关键词：
TUMOR 1-ASSOCIATING PROTEIN; MESSENGER-RNA; METHYLATED NUCLEOSIDES; CANDIDATE GENES; RIBOSOMAL-RNA; NUCLEAR-RNA; FTO GENE; HUR; N-6-METHYLADENOSINE; ALKB;
D O I：
10.1016/j.trsl.2014.04.003
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Mammalian messenger RNA (mRNA) and long noncoding RNA (IncRNA) contain tens of thousands of posttranscriptional chemical modifications. Among these, the N-6-methyl-adenosine (m(6)A) modification is the most abundant and can be removed by specific mammalian enzymes. m(6)A modification is recognized by families of RNA binding proteins that affect many aspects of mRNA function. mRNA/IncRNA modification represents another layer of epigenetic regulation of gene expression, analogous to DNA methylation and histone modification.
引用
收藏
页码：28 / 35
页数：8
相关论文
共 80 条
[1]   MODIFIED NUCLEOSIDES AND BIZARRE 5'-TERMINI IN MOUSE MYELOMA MESSENGER-RNA [J].
ADAMS, JM ;
CORY, S .
NATURE, 1975, 255 (5503) :28-33
[2]   Decoding the genome: a modified view [J].
Agris, PF .
NUCLEIC ACIDS RESEARCH, 2004, 32 (01) :223-238
[3]  
Akilzhanova A, 2013, ANTICANCER RES, V33, P4049
[4]   The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae [J].
Anderson, J ;
Phan, L ;
Hinnebusch, AG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) :5173-5178
[5]   PREVENTION OF TRANSLATIONAL FRAMESHIFTING BY THE MODIFIED NUCLEOSIDE 1-METHYLGUANOSINE [J].
BJORK, GR ;
WIKSTROM, PM ;
BYSTROM, AS .
SCIENCE, 1989, 244 (4907) :986-989
[6]  
Bokar JA, 1997, RNA, V3, P1233
[7]  
Bokar JA, 2005, TOP CURR GENET, V12, P141, DOI 10.1007/b106365
[8]   Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m6 a methyltransferase [J].
Bujnicki, JM ;
Feder, M ;
Radlinska, M ;
Blumenthal, RM .
JOURNAL OF MOLECULAR EVOLUTION, 2002, 55 (04) :431-444
[9]   A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity [J].
Cardelli, Maurizio ;
Marchegiani, Francesca ;
Cavallone, Luca ;
Olivieri, Fabiola ;
Giovagnetti, Simona ;
Mugianesi, Elena ;
Moresi, Raffaella ;
Lisa, Rosamaria ;
Franceschi, Claudio .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2006, 61 (06) :547-556
[10]   A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene [J].
Church, Chris ;
Lee, Sheena ;
Bagg, Eleanor A. L. ;
McTaggart, James S. ;
Deacon, Robert ;
Gerken, Thomas ;
Lee, Angela ;
Moir, Lee ;
Mecinovic, Jasmin ;
Quwailid, Mohamed M. ;
Schofield, Christopher J. ;
Ashcroft, Frances M. ;
Cox, Roger D. .
PLOS GENETICS, 2009, 5 (08)
12345678