Changes in White Matter Microstructure Impact Cognition by Disrupting the Ability of Neural Assemblies to Synchronize

被引:46
作者
Bells, Sonya [1 ]
Lefebvre, Jeremie [7 ,10 ]
Prescott, Steven A. [1 ,9 ]
Dockstader, Colleen [6 ]
Bouffet, Eric [2 ,5 ]
Skocic, Jovanka [1 ]
Laughlin, Suzanne [3 ,8 ]
Mabbott, Donald J. [1 ,4 ]
机构
[1] Hosp Sick Children, Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada
[2] Hosp Sick Children, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada
[3] Hosp Sick Children, Diagnost Imaging, Toronto, ON M5G 1X8, Canada
[4] Univ Toronto, Inst Biomat & Biomed Engn, Dept Psychol, Toronto, ON M5S 1A1, Canada
[5] Univ Toronto, Inst Biomat & Biomed Engn, Dept Paediat, Toronto, ON M5S 1A1, Canada
[6] Univ Toronto, Inst Biomat & Biomed Engn, Dept Human Biol Program, Toronto, ON M5S 1A1, Canada
[7] Univ Toronto, Inst Biomat & Biomed Engn, Dept Math, Toronto, ON M5S 1A1, Canada
[8] Univ Toronto, Inst Biomat & Biomed Engn, Dept Med Imaging, Toronto, ON M5S 1A1, Canada
[9] Univ Toronto, Inst Biomat & Biomed Engn, Dept Physiol, Toronto, ON M5S 1A1, Canada
[10] Univ Hlth Network, Krembil Res Inst, Toronto, ON M5G 2C4, Canada
基金
加拿大健康研究院;
关键词
cognition; diffusion MRI; information processing speed; MEG; neural synchrony; white matter; DIFFUSION TENSOR; REACTION-TIME; NEURONAL SYNCHRONIZATION; CONDUCTION-VELOCITY; SPATIAL ATTENTION; PROCESSING SPEED; VISUAL-CORTEX; BRAIN-TUMORS; CHILDREN; OSCILLATIONS;
D O I
10.1523/JNEUROSCI.0560-17.2017
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Cognition is compromised by white matter (WM) injury but the neurophysiological alterations linking them remain unclear. Wehypothesized that reduced neural synchronization caused by disruption of neural signal propagation is involved. To test this, we evaluated group differences in: diffusion tensor WM microstructure measures within the optic radiations, primary visual area (V1), and cuneus; neural phase synchrony to a visual attention cue during visual-motor task; and reaction time to a response cue during the same task between 26 pediatric patients (17/9: male/female) treated with cranial radiation treatment for a brain tumor (12.67 +/- 2.76 years), and 26 healthy children (16/10: male/female; 12.01 +/- 3.9 years). We corroborated our findings using a corticocortical computational model representing perturbed signal conduction from myelin. Patients show delayed reaction time, WM compromise, and reduced phase synchrony during visual attention compared with healthy children. Notably, using partial least-squares-path modeling we found that WM insult within the optic radiations, V1, and cuneus is a strong predictor of the slower reaction times via disruption of neural synchrony in visual cortex. Observed changes in synchronization were reproduced in a computational model of WM injury. These findings provide new evidence linking cognition with WM via the reliance of neural synchronization on propagation of neural signals.
引用
收藏
页码:8227 / 8238
页数:12
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