Reduced genetic potential for butyrate fermentation in the gut microbiome of infants who develop allergic sensitization

被引:116
作者
Cait, Alissa [1 ]
Cardenas, Erick [1 ]
Dimitriu, Pedro A. [1 ]
Amenyogbe, Nelly [1 ]
Dai, Darlene [2 ]
Cait, Jessica [3 ]
Sbihi, Hind [2 ]
Stiemsma, Leah [1 ,2 ]
Subbarao, Padmaja [4 ,5 ]
Mandhane, Piush J. [6 ,7 ]
Becker, Allen B. [8 ]
Moraes, Theo J. [4 ,5 ]
Sears, Malcolm R. [9 ]
Lefebvre, Diana L. [9 ]
Azad, Meghan B. [10 ]
Kollmann, Tobias [2 ]
Turvey, Stuart E. [2 ]
Mohn, William W. [1 ]
机构
[1] Univ British Columbia, Life Sci Inst, Dept Microbiol & Immunol, Vancouver, BC, Canada
[2] Univ British Columbia, BC Childrens Hosp, Dept Pediat, Vancouver, BC, Canada
[3] Univ British Columbia, Biomed Res Ctr, Vancouver, BC, Canada
[4] Univ Toronto, Dept Pediat & Physiol, Toronto, ON, Canada
[5] Hosp Sick Children, Toronto, ON, Canada
[6] Univ Alberta, Dept Pediat, Edmonton, AB, Canada
[7] Univ Alberta, Sch Publ Hlth, Edmonton, AB, Canada
[8] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB, Canada
[9] McMaster Univ, Dept Med, Hamilton, ON, Canada
[10] Univ Manitoba, Childrens Hosp, Dev Origins Chron Dis Children Network DEVOTION, Dept Pediat & Child Hlth,Res Inst Manitoba, Winnipeg, MB, Canada
基金
加拿大健康研究院;
关键词
Atopy; microbiome; metagenome; butyrate; LONGITUDINAL DEVELOPMENT CHILD; REGULATORY T-CELLS; CHAIN FATTY-ACIDS; ATOPIC-DERMATITIS; DIETARY FIBER; BIRTH COHORT; ASTHMA; DISEASE; RISK; DEGRADATION;
D O I
10.1016/j.jaci.2019.06.029
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Allergic disease is the most frequent chronic health issue in children and has been linked to early-life gut microbiome dysbiosis. Many lines of evidence suggest that microbially derived short-chain fatty acids, and particularly butyrate, can promote immune tolerance. Objective: We sought to determine whether bacterial butyrate production in the gut during early infancy is protective against the development of atopic disease in children. Methods: We used shotgun metagenomic analysis to determine whether dysbiosis in butyrate fermentation could be identified in human infants, before their developing allergic disease. Results: We found that the microbiome of infants who went on to develop allergic sensitization later in childhood lacked genes encoding key enzymes for carbohydrate breakdown and butyrate production. Conclusions: Our findings support the importance of microbial carbohydrate metabolism during early infancy in protecting against the development of allergies.
引用
收藏
页码:1638 / +
页数:13
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