Similar long-term swallowing outcomes for accelerated, mildly-hypofractionated radiotherapy compared to conventional fractionation in oropharyngeal cancer: A multi-centre study

被引：1

作者：

Price, James M. ^{[1
,2
]}

West, Catharine M. ^{[2
]}

Dixon, Lynne M. ^{[3
]}

Iyizoba-Ebozue, Zsuzsanna ^{[4
]}

Garcez, Kate ^{[1
]}

Lee, Lip Wai ^{[1
]}

McPartlin, Andrew ^{[1
]}

Slevin, Fin ^{[4
]}

Sykes, Andrew ^{[1
]}

Prestwich, Robin J. D. ^{[4
]}

Thomson, David J. ^{[1
,2
,5
]}

机构：

[1] Christie NHS Fdn Trust, Dept Clin Oncol, Manchester, England

[2] Univ Manchester, Christie NHS Fdn Trust, Fac Biol, Div Canc Sci, Manchester, England

[3] Sheffield Teaching Hosp NHS Fdn Trust, Weston Pk Hosp, Sheffield, England

[4] Leeds Canc Ctr, Dept Clin Oncol, Leeds, England

[5] Christie NHS Fdn Trust, Dept Clin Oncol, Wilmslow Rd, Manchester M20 4BX, England

来源：

RADIOTHERAPY AND ONCOLOGY | 2022年 / 172卷

关键词：

Oropharyngeal cancer; Radiotherapy; Fractionation; Hypofractionation; Late effects; Patient reported outcomes; INTENSITY-MODULATED RADIOTHERAPY; SQUAMOUS-CELL CARCINOMA; T3N0 GLOTTIC CARCINOMA; QUALITY-OF-LIFE; NECK-CANCER; HEAD; CHEMOTHERAPY; CHEMORADIATION; DYSFUNCTION; TRIALS;

D O I：

10.1016/j.radonc.2022.05.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and purpose: There is renewed interest in hypofractionated radiotherapy, but limited data and a lack of consensus to support use for head and neck cancer. In this multicentre analysis we compared outcomes for patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with conventional and accelerated, mildly hypofractionated radiotherapy without chemotherapy. Materials and methods: A multi-centre, observational study of consecutive OPSCCs treated between 2015 and 2018. Patients underwent curative-intent radiotherapy (oropharyngeal and bilateral neck) using conventionally fractionated (70 Gy in 35 fractions over 7 weeks, n = 97) or accelerated, mildly hypofractionated (65-66 Gy in 30 fractions over 6 weeks, n = 136) radiotherapy without chemotherapy. Locoregional control (LRC) and overall survival (OS) were compared. Patients alive and cancer-free at a minimum of 2 years post-radiotherapy (n = 151, 65%) were sent an MD Anderson Dysphagia Inventory (MDADI) questionnaire to assess swallow function. Results: LRC and OS were similar across schedules (p = 0.78 and 0.95 respectively, log-rank test). Enteral feeding rates during radiotherapy appeared higher in the 7-week group though this did not reach statistical significance (59% vs 48%, p = 0.08). Feeding rates were similar at 1 year post radiotherapy for both groups (10% vs 6%, p = 0.27). 107 patients returned MDADI questionnaires (71%); there were no differences between the 6- and 7-week groups for median global (60.0 vs 60.0, p = 0.99) and composite (65.8 vs 64.2, p = 0.44) MDADI scores. Conclusion: Patients with OPSCC treated with radiotherapy alone have similar swallowing outcomes, LRC and OS following accelerated, mild hypofractionation and standard fractionation schedules, supporting its use as a standard-of-care option for patients unsuitable for concurrent chemotherapy. (c) 2022 Elsevier B.V. All rights reserved. Radiotherapy and Oncology 172 (2022) 111-117

引用

页码：111 / 117

页数：7

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