Molecular mechanisms underlying hepatitis C virus infection-related diabetes

被引：11
作者：
Ding, Yujin [1 ,2 ,3 ,4 ]
Li, Guangdi [6 ]
Zhou, Zhiguang [1 ,2 ,3 ,4 ]
Deng, Tuo [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Cent South Univ, Natl Clin Res Ctr Metab Dis, Second Xiangya Hosp, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[2] Cent South Univ, Dept Endocrinol & Metab, Second Xiangya Hosp, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[3] Cent South Univ, Key Lab Diabet Immunol, Second Xiangya Hosp, Minist Educ, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[4] Cent South Univ, Metab Syndrome Res Ctr, Second Xiangya Hosp, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[5] Cent South Univ, Clin Immunol Ctr, Second Xiangya Hosp, Changsha 410011, Hunan, Peoples R China
[6] Cent South Univ, Hunan Prov Key Lab Clin Epidemiol, Xiangya Sch Publ Hlth, Changsha 410011, Hunan, Peoples R China
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL | 2021年 / 121卷
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Diabetes; insulin resistance; Hepatitis C virus; Islet beta-cell; microRNA; INSULIN-RECEPTOR SUBSTRATE-1; GENOME-WIDE ASSOCIATION; FATTY LIVER-DISEASE; CORE PROTEIN; SIGNALING PATHWAY; BETA-CELL; SERINE PHOSPHORYLATION; CIRCULATING MICRORNAS; METABOLIC SYNDROME; OXIDATIVE STRESS;
D O I：
10.1016/j.metabol.2021.154802
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetes is a noncommunicable widespread disease that poses the risk of severe complications in patients, with certain complications being life-threatening. Hepatitis C is an infectious disease that mainly causes liver damage, which is also a profound threat to human health. Hepatitis C virus (HCV) infection has many extrahepatic manifestations, including diabetes. Multiple mechanisms facilitate the strong association between HCV and diabetes. HCV infection can affect the insulin signaling pathway in liver and pancreatic tissue and change the profiles of circulating microRNAs, which may further influence the occurrence and development of diabetes. This review describes how HCV infection causes diabetes and discusses the current research progress with respect to HCV infection-related diabetes. (c) 2021 Published by Elsevier Inc.
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页数：9
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