Molecular mechanisms underlying hepatitis C virus infection-related diabetes

被引：9
|
作者：
Ding, Yujin [1 ,2 ,3 ,4 ]
Li, Guangdi [6 ]
Zhou, Zhiguang [1 ,2 ,3 ,4 ]
Deng, Tuo [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Cent South Univ, Natl Clin Res Ctr Metab Dis, Second Xiangya Hosp, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[2] Cent South Univ, Dept Endocrinol & Metab, Second Xiangya Hosp, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[3] Cent South Univ, Key Lab Diabet Immunol, Second Xiangya Hosp, Minist Educ, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[4] Cent South Univ, Metab Syndrome Res Ctr, Second Xiangya Hosp, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[5] Cent South Univ, Clin Immunol Ctr, Second Xiangya Hosp, Changsha 410011, Hunan, Peoples R China
[6] Cent South Univ, Hunan Prov Key Lab Clin Epidemiol, Xiangya Sch Publ Hlth, Changsha 410011, Hunan, Peoples R China
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL | 2021年 / 121卷
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
Diabetes; insulin resistance; Hepatitis C virus; Islet beta-cell; microRNA; INSULIN-RECEPTOR SUBSTRATE-1; GENOME-WIDE ASSOCIATION; FATTY LIVER-DISEASE; CORE PROTEIN; SIGNALING PATHWAY; BETA-CELL; SERINE PHOSPHORYLATION; CIRCULATING MICRORNAS; METABOLIC SYNDROME; OXIDATIVE STRESS;
D O I：
10.1016/j.metabol.2021.154802
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetes is a noncommunicable widespread disease that poses the risk of severe complications in patients, with certain complications being life-threatening. Hepatitis C is an infectious disease that mainly causes liver damage, which is also a profound threat to human health. Hepatitis C virus (HCV) infection has many extrahepatic manifestations, including diabetes. Multiple mechanisms facilitate the strong association between HCV and diabetes. HCV infection can affect the insulin signaling pathway in liver and pancreatic tissue and change the profiles of circulating microRNAs, which may further influence the occurrence and development of diabetes. This review describes how HCV infection causes diabetes and discusses the current research progress with respect to HCV infection-related diabetes. (c) 2021 Published by Elsevier Inc.
引用
收藏
页数：9
相关论文
共 50 条
  • [1] Hepatitis C virus infection-related Type 1 diabetes mellitus
    Chen, LK
    Chou, YC
    Tsai, ST
    Hwang, SJ
    Lee, SD
    DIABETIC MEDICINE, 2005, 22 (03) : 340 - 343
  • [2] Hepatitis C virus infection and diabetes
    Das, Gautam
    Bolusani, Hemanth
    PRACTICAL DIABETES, 2016, 33 (04) : 121 - 128
  • [3] Hepatitis C Virus Infection: Molecular Pathways to Insulin resistance
    Parvaiz, Fahed
    Manzoor, Sobia
    Tariq, Huma
    Javed, Farakh
    Fatima, Kaneez
    Qadri, Ishtiaq
    VIROLOGY JOURNAL, 2011, 8
  • [4] Diabetes mellitus, insulin resistance and hepatitis C virus infection: A contemporary review
    Desbois, Anne-Claire
    Cacoub, Patrice
    WORLD JOURNAL OF GASTROENTEROLOGY, 2017, 23 (09) : 1697 - 1711
  • [5] Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection
    Yamashita, Taro
    Honda, Masao
    Kaneko, Shuichi
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2011, 26 (06) : 960 - 964
  • [6] Regulation of insulin resistance and type II diabetes by hepatitis C virus infection: A driver function of circulating miRNAs
    Singhal, Adit
    Agrawal, Aniruddh
    Ling, Jun
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2018, 22 (04) : 2071 - 2085
  • [7] Dual Infection with Hepatitis B Virus and Hepatitis C Virus Correlated with Type 2 Diabetes Mellitus
    Lin, Ping-Yi
    Chen, Shu-Chu
    Lo, Tsai-Chang
    Kuo, Hsien-Wen
    EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2020, 128 (01) : 38 - 42
  • [8] Circulating autoantibodies to endogenous erythropoietin are associated with chronic hepatitis C virus infection-related anemia
    Tsiakalos, Aristotelis
    Voumvas, Theoharis
    Psarris, Alexandros
    Oikonomou, Christina K.
    Ziogas, Dimitrios C.
    Ketikoglou, Ioannis
    Hatzis, Grigorios
    Sipsas, Nikolaos V.
    HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, 2017, 16 (03) : 289 - 295
  • [9] Circulating autoantibodies to endogenous erythropoietin are associated with chronic hepatitis C virus infection-related anemia
    Aristotelis Tsiakalos
    Theoharis Voumvas
    Alexandros Psarris
    Christina K Oikonomou
    Dimitrios C Ziogas
    Ioannis Ketikoglou
    Grigorios Hatzis
    Nikolaos V Sipsas
    Hepatobiliary & Pancreatic Diseases International, 2017, 16 (03) : 289 - 295
  • [10] Molecular mechanisms of hepatitis C virus-induced hepatocellular carcinoma
    Vescovo, T.
    Refolo, G.
    Vitagliano, G.
    Fimia, G. M.
    Piacentini, M.
    CLINICAL MICROBIOLOGY AND INFECTION, 2016, 22 (10) : 853 - 861
12345