共 178 条
TOR Signaling and Nutrient Sensing
被引:325
作者:
Dobrenel, Thomas
[1
,2
]
Caldana, Camila
[3
]
Hanson, Johannes
[2
]
Robaglia, Christophe
[4
]
Vincentz, Michel
[5
]
Veit, Bruce
[6
]
Meyer, Christian
[1
]
机构:
[1] AgroParisTech, Saclay Plant Sci, CNRS 3559, ERL,Inst Jean Pierre Bourgin,INRA,UMR 1318, F-78026 Versailles, France
[2] Umea Univ, Dept Plant Physiol, Umea Plant Sci Ctr, S-90187 Umea, Sweden
[3] Brazilian Bioethanol Sci & Technol Lab, Max Planck Partner Grp, Mol Physiol Plant Biomass Prod Grp, BR-13083100 Sao Paulo, Brazil
[4] Aix Marseille Univ, Fac Sci Luminy, Lab Genet & Biophys Plantes, DSV,IBEB,SBVME,CEA,CNRS,UMR 7265, F-13009 Marseille, France
[5] Univ Estadual Campinas, Ctr Biol Mol & Engn Genet, Lab Genet Plantas, BR-13083875 Sao Paulo, Brazil
[6] Massey Univ, Inst Fundamental Sci, AgRes, Forage Improvement, Palmerston North 4442, New Zealand
来源:
ANNUAL REVIEW OF PLANT BIOLOGY, VOL 67
|
2016年
/
67卷
基金:
巴西圣保罗研究基金会;
关键词:
TOR kinase;
SnRK1;
kinase;
nutrient signaling;
sugars;
nitrogen;
REGULATORY SUBUNIT TAP46;
WD-REPEAT PROTEIN;
PLANT-GROWTH;
ARABIDOPSIS-THALIANA;
RAPAMYCIN TOR;
S6;
KINASE;
TRIACYLGLYCEROL ACCUMULATION;
EVOLUTIONARY CONSERVATION;
SACCHAROMYCES-CEREVISIAE;
TREHALOSE METABOLISM;
D O I:
10.1146/annurev-arplant-043014-114648
中图分类号:
Q94 [植物学];
学科分类号:
071001 ;
摘要:
All living organisms rely on nutrients to sustain cell metabolism and energy production, which in turn need to be adjusted based on available resources. The evolutionarily conserved target of rapamycin (TOR) protein kinase is a central regulatory hub that connects environmental information about the quantity and quality of nutrients to developmental and metabolic processes in order to maintain cellular homeostasis. TOR is activated by both nitrogen and carbon metabolites and promotes energy-consuming processes such as cell division, mRNA translation, and anabolism in times of abundance while repressing nutrient remobilization through autophagy. In animals and yeasts, TOR acts antagonistically to the starvation-induced AMP-activated kinase (AMPK)/sucrose nonfermenting 1 (Snf1) kinase, called Snf1-related kinase 1 (SnRK1) in plants. This review summarizes the immense knowledge on the relationship betweenTORsignaling and nutrients in nonphotosynthetic organisms and presents recent findings in plants that illuminate the crucial role of this pathway in conveying nutrient-derived signals and regulating many aspects of metabolism and growth.
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页码:261 / 285
页数:25
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