Limonoids isolated from Toona sinensis and their radical scavenging, anti-inflammatory and cytotoxic activities

被引：62
作者：
Hu, Jiang [1 ]
Song, Yan [2 ]
Mao, Xia [1 ]
Wang, Zhen-Ji [3 ]
Zhao, Qin-Jie [4 ]
机构：
[1] Qujing Normal Univ, Coll Biol Resources & Environm Sci, Qujing 655011, Peoples R China
[2] Peoples Liberat Army, Hosp 455, Dept Pharm, Shanghai 200052, Peoples R China
[3] Chuxiong Normal Univ, Dept Chem & Life Sci, Chuxiong 675000, Peoples R China
[4] Second Mil Med Univ, Dept Organ Chem, Coll Pharm, Shanghai 200433, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2016年 / 20卷
基金：
中国国家自然科学基金;
关键词：
Toona sinensis; Meliaceae; Limonoids; Radical scavenging; Anti-inflammatory; Cytotoxic activities; LEAF EXTRACT; AQUEOUS EXTRACT; WATER EXTRACT; ALKALOIDS; APOPTOSIS; LIGNANS; LEAVES; ROEMOR;
D O I：
10.1016/j.jff.2015.10.009
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
A phytochemical investigation of the ethanol extract of Toona sinensis (A. fuss.) Roem resulted in the isolation of ten new limonoids, toonasinenines A-J (1-10), together with two known compounds, toonafolin (11) and toonacilianin D (12). Their structures were determined by spectroscopic analyses. The isolated components were evaluated in vitro for radical scavenging potential using ABTS(+) and DPPH test, anti-inflammatory activities for Cox-1 and Cox-2, and cytotoxicies against nine tumour cell lines (A549, BGC-823, CHG-5, HCT15, HeLa, HepG2, MDA-MB-231, SHG-44 and SGC-7901 cells). As a result, 4, 5 and 7-10 showed potent radical scavenging activities, while limonoids 1-4 and 11 exhibited significant anti-inflammatory and cytotoxic potential. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1 / 9
页数：9
相关论文
共 25 条
[1]   The fractionated Toona sinensis leaf extract induces apoptosis of human ovarian cancer cells and inhibits tumor growth in a murine xenograft model [J].
Chang, Hsueh-Ling ;
Hsu, Hseng-Kuang ;
Su, Jinu-Huang ;
Wang, Pei-Hui ;
Chung, Yueh-Fang ;
Chia, Yi-Chen ;
Tsai, Li-Yu ;
Wu, Yang-Chang ;
Yuan, Shyng-Shiou F. .
GYNECOLOGIC ONCOLOGY, 2006, 102 (02) :309-314
[2]   Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication [J].
Chen, Chung-Jen ;
Michaelis, Martin ;
Hsu, Hseng-Kuang ;
Tsai, Chin-Chuan ;
Yang, Kunder D. ;
Wu, Yang-Chang ;
Cinatl, Jindrich, Jr. ;
Doerr, Hans Wilhelm .
JOURNAL OF ETHNOPHARMACOLOGY, 2008, 120 (01) :108-111
[3]   Effects of water extract from anaerobic fermented Toona sinensis Roemor on the expression of antioxidant enzymes in the Sprague-Dawley Rats [J].
Chen, Gen-Hung ;
Huang, Feng-Sheng ;
Lin, Yen-Chang ;
Hsu, Cheng-Kuang ;
Chung, Yun-Chin .
JOURNAL OF FUNCTIONAL FOODS, 2013, 5 (02) :773-780
[4]   Aporphine alkaloids and cytotoxic lignans from the roots of Illigera luzonensis [J].
Chen, Jih-Jung ;
Hung, Hsin-Chih ;
Sung, Ping-Jyun ;
Chen, Ih-Sheng ;
Kuo, Wen-Lung .
PHYTOCHEMISTRY, 2011, 72 (06) :523-532
[5]   Mechanism of Toona sinensis-stimulated adrenal steroidogenesis in primary rat adrenal cells [J].
Chen, Yung-Chia ;
Liang, Yi-Lin ;
Huang, Yuan-Li ;
Huang, Bu-Miin .
JOURNAL OF FUNCTIONAL FOODS, 2015, 14 :318-323
[6]   Toona sinensis (aqueous leaf extracts) induces apoptosis through the generation of ROS and activation of intrinsic apoptotic pathways in human renal carcinoma cells [J].
Chen, Yung-Chia ;
Chien, Ling-Hui ;
Huang, Bu-Miin ;
Chia, Yi-Chen .
JOURNAL OF FUNCTIONAL FOODS, 2014, 7 :362-372
[7]   Analysis of antioxidant activity and antioxidant constituents of Chinese toon [J].
Cheng, Ka-Wing ;
Yang, Ray-Yu ;
Tsou, Samson C. S. ;
Lo, Clive S. C. ;
Ho, Chi-Tang ;
Lee, Tung-Ching ;
Wang, Mingfu .
JOURNAL OF FUNCTIONAL FOODS, 2009, 1 (03) :253-259
[8]  
Edmonds Jennifer M., 1998, Curtis's Botanical Magazine, V15, P186, DOI 10.1111/1467-8748.00169
[9]   Anti-inflammatory sesquiterpene pyridine alkaloids from Tripterygium wilfordii [J].
Gao, Chang ;
Huang, Xiao-Xiao ;
Bai, Ming ;
Wu, Jie ;
Li, Jian-You ;
Liu, Qing-Bo ;
Li, Ling-Zhi ;
Song, Shao-Jiang .
FITOTERAPIA, 2015, 105 :49-54
[10]  
Gasca C. A., 2013, Free Radicals and Antioxidants, V3, pS55
123