Rhodomollanol A, a Highly Oxygenated Diterpenoid with a 5/7/5/5 Tetracyclic Carbon Skeleton from the Leaves of Rhododendron molle

被引：55

作者：

Zhou, Junfei ^{[1
]}

Zhan, Guanqun ^{[1
]}

Zhang, Hanqi ^{[1
]}

Zhang, Qihua ^{[1
]}

Li, Ying ^{[1
]}

Xue, Yongbo ^{[1
]}

Yao, Guangmin ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 14期

基金：

中国国家自然科学基金;

关键词：

GRAYANANE DITERPENOIDS; FRUITS; ROOTS; FLOWERS; GRAYANOIDS;

D O I：

10.1021/acs.orglett.7b01863

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel diterpenoid with an unprecedented carbon skeleton, rhodomollanol A (1), and a new grayanane diterpenoid, rhodomollein XXXI (2), were isolated from the leaves of Rhododendron molle. Their structures were elucidated using comprehensive spectroscopic methods and single-crystal X-ray diffraction. Compound 1 possesses a unique cis/trans/trans/cis/cis-fused 3/5/7/5/5/5 hexacyclic ring system featuring a rare 7-oxabicyclo[4.2.1]nonane core decorated with three cyclopentane units. The plausible biosynthetic pathway for 1 was proposed. Compound 1 exhibited moderate PTP1B inhibitory activity.

引用

页码：3935 / 3938

页数：4

共 27 条

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