SELF-ASSEMBLED PARTICLES BASED ON HYDROPHOBICALLY MODIFIED CHITOSAN

被引：0
|
作者：
Poshina, Daria N. [1 ]
Novitskaya, Vlada V. [1 ]
Raik, Sergei, V [1 ]
Skorik, Yury A. [1 ]
机构：
[1] Russian Acad Sci, Inst Macromol Cpds, Bolshoi Pr VO 31, St Petersburg 199004, Russia
来源：
PROCEEDINGS OF THE 16TH INTERNATIONAL CONFERENCE ON POLYSACCHARIDES-GLYCOSCIENCE | 2020年
基金：
俄罗斯科学基金会;
关键词：
DELIVERY;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Non-viral gene delivery is a promising but challenging field of biomedical sciences. In recent years, cationic chitosan derivatives have been thoroughly studied as gene delivery systems; however, their efficiency is still rather low. We have developed hydrophobically modified chitosans bearing deoxycholic acid and tocopherol substituents. The modified chitosans form self-assembled particles, and our obtained results indicate possible interaction of our chitosans with nucleic acids. These findings suggest that these modified chitosans warrant further investigation for an ability to promote transfection.
引用
收藏
页码：102 / 104
页数：3
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