Neonatal Seizures: An Update on Mechanisms and Management

被引：100
作者：
Jensen, Frances E. [1 ]
机构：
[1] Childrens Hosp Boston, Boston, MA 02115 USA
来源：
CLINICS IN PERINATOLOGY | 2009年 / 36卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Epilepsy; Perinatal; Synapse; Neurotransmitter receptor; Glutamate; gamma-aminobutyric acid (GABA); CEREBRAL WHITE-MATTER; AMPLITUDE-INTEGRATED ELECTROENCEPHALOGRAPHY; GABAERGIC SYNAPTIC-TRANSMISSION; RECEPTOR SUBUNIT EXPRESSION; HYPOXIA-INDUCED SEIZURES; WHOLE-BODY HYPOTHERMIA; BIRTH-WEIGHT INFANTS; LONG-TERM; ANTIEPILEPTIC DRUGS; DEVELOPMENTAL REGULATION;
D O I：
10.1016/j.clp.2009.08.001
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The lifespan risk of seizures is highest in the neonatal period. Current therapies have limited efficacy. Although the treatment of neonatal seizures has not changed significantly in the last several decades, there has been substantial progress in understanding developmental mechanisms that influence seizure generation and responsiveness to anticonvulsants. This article provides an overview of current approaches to the diagnosis and treatment of neonatal seizures, and some of the recent insights about the pathophysiology of neonatal seizures that may provide the foundation for better treatment are identified.
引用
收藏
页码：881 / +
页数：21
相关论文
共 133 条
  • [71] LAWRENCE R, 2009, J PEDIAT, V154
  • [72] Minocycline treatment following hypoxic/ischaemic injury attenuates white matter injury in a rodent model of periventricular leucomalacia
    Lechpammer, M.
    Manning, S. M.
    Samonte, F.
    Nelligan, J.
    Sabo, E.
    Talos, D. M.
    Volpe, J. J.
    Jensen, F. E.
    [J]. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2008, 34 (04) : 379 - 393
  • [73] Subplate neuron ablation alters neurotrophin expression and ocular dominance column formation
    Lein, ES
    Finney, EM
    McQuillen, PS
    Shatz, CJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (23) : 13491 - 13495
  • [74] Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats
    Liu, YQ
    Barks, JD
    Xu, G
    Silverstein, FS
    [J]. STROKE, 2004, 35 (06) : 1460 - 1465
  • [75] GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis
    LoTurco, JJ
    Owens, DF
    Heath, MJS
    Davis, MBE
    Kriegstein, AR
    [J]. NEURON, 1995, 15 (06) : 1287 - 1298
  • [76] The age of plasticity: developmental regulation of synaptic plasticity in neocortical microcircuits
    Maffei, Arianna
    Turrigiano, Gina
    [J]. ESSENCE OF MEMORY, 2008, 169 : 211 - 223
  • [77] Development of an optimal lidocaine infusion strategy for neonatal seizures
    Malingre, Mirte M.
    Van Rooij, Linda G. M.
    Rademaker, Carin M. A.
    Toet, Mona C.
    Ververs, Tessa F. F. T.
    van Kesteren, Charlotte
    Vries, Linda S. de
    [J]. EUROPEAN JOURNAL OF PEDIATRICS, 2006, 165 (09) : 598 - 604
  • [78] NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia
    Manning, Simon M.
    Talos, Delia M.
    Zhou, Chengwen
    Selip, Debra B.
    Park, Hyun-Kyung
    Park, Chang-Joo
    Volpe, Joseph J.
    Jensen, Frances E.
    [J]. JOURNAL OF NEUROSCIENCE, 2008, 28 (26) : 6670 - 6678
  • [79] Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain
    Manthey, D
    Asimiadou, S
    Stefovska, V
    Kaindl, AM
    Fassbender, J
    Ikonomidou, C
    Bittigau, P
    [J]. EXPERIMENTAL NEUROLOGY, 2005, 193 (02) : 497 - 503
  • [80] Different effects of two N-methyl-D-aspartate receptor antagonists on seizures, spontaneous behavior, and motor performance in immature rats
    Mares, Pavel
    Mikulecka, Anna
    [J]. EPILEPSY & BEHAVIOR, 2009, 14 (01) : 32 - 39
3456789101112