Neonatal Seizures: An Update on Mechanisms and Management

被引：100

作者：

Jensen, Frances E. ^{[1
]}

机构：

[1] Childrens Hosp Boston, Boston, MA 02115 USA

来源：

CLINICS IN PERINATOLOGY | 2009年 / 36卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Epilepsy; Perinatal; Synapse; Neurotransmitter receptor; Glutamate; gamma-aminobutyric acid (GABA); CEREBRAL WHITE-MATTER; AMPLITUDE-INTEGRATED ELECTROENCEPHALOGRAPHY; GABAERGIC SYNAPTIC-TRANSMISSION; RECEPTOR SUBUNIT EXPRESSION; HYPOXIA-INDUCED SEIZURES; WHOLE-BODY HYPOTHERMIA; BIRTH-WEIGHT INFANTS; LONG-TERM; ANTIEPILEPTIC DRUGS; DEVELOPMENTAL REGULATION;

D O I：

10.1016/j.clp.2009.08.001

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The lifespan risk of seizures is highest in the neonatal period. Current therapies have limited efficacy. Although the treatment of neonatal seizures has not changed significantly in the last several decades, there has been substantial progress in understanding developmental mechanisms that influence seizure generation and responsiveness to anticonvulsants. This article provides an overview of current approaches to the diagnosis and treatment of neonatal seizures, and some of the recent insights about the pathophysiology of neonatal seizures that may provide the foundation for better treatment are identified.

引用

页码：881 / +

页数：21

共 133 条

[91] Antiepileptic drugs trials: Neonates and infants [J].