Neonatal Seizures: An Update on Mechanisms and Management

被引：100
作者：
Jensen, Frances E. [1 ]
机构：
[1] Childrens Hosp Boston, Boston, MA 02115 USA
来源：
CLINICS IN PERINATOLOGY | 2009年 / 36卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Epilepsy; Perinatal; Synapse; Neurotransmitter receptor; Glutamate; gamma-aminobutyric acid (GABA); CEREBRAL WHITE-MATTER; AMPLITUDE-INTEGRATED ELECTROENCEPHALOGRAPHY; GABAERGIC SYNAPTIC-TRANSMISSION; RECEPTOR SUBUNIT EXPRESSION; HYPOXIA-INDUCED SEIZURES; WHOLE-BODY HYPOTHERMIA; BIRTH-WEIGHT INFANTS; LONG-TERM; ANTIEPILEPTIC DRUGS; DEVELOPMENTAL REGULATION;
D O I：
10.1016/j.clp.2009.08.001
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The lifespan risk of seizures is highest in the neonatal period. Current therapies have limited efficacy. Although the treatment of neonatal seizures has not changed significantly in the last several decades, there has been substantial progress in understanding developmental mechanisms that influence seizure generation and responsiveness to anticonvulsants. This article provides an overview of current approaches to the diagnosis and treatment of neonatal seizures, and some of the recent insights about the pathophysiology of neonatal seizures that may provide the foundation for better treatment are identified.
引用
收藏
页码：881 / +
页数：21
相关论文
共 133 条
[1]   CONVULSIVE STATUS EPILEPTICUS IN INFANTS AND CHILDREN - A STUDY OF 239 CASES [J].
AICARDI, J ;
CHEVRIE, JJ .
EPILEPSIA, 1970, 11 (02) :187-&
[2]   Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model [J].
Aujla, Paven K. ;
Fetell, Michael R. ;
Jensen, Frances E. .
EPILEPSIA, 2009, 50 (04) :694-701
[3]   The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: A randomised controlled trial [J].
Azzopardi, D. ;
Brocklehurst, P. ;
Edwards, D. ;
Halliday, H. ;
Levene, M. ;
Thoresen, M. ;
Whitelaw, A. .
BMC PEDIATRICS, 2008, 8 (1)
[4]   Neuropeptide-mediated excitability: a key triggering mechanism for seizure generation in the developing brain [J].
Baram, TZ ;
Hatalski, CG .
TRENDS IN NEUROSCIENCES, 1998, 21 (11) :471-476
[5]   Neonatal seizures: Multicenter variability in current treatment practices [J].
Bartha, Agnes I. ;
Shen, Jessica ;
Katz, Karol H. ;
Mischel, Rebecca E. ;
Yap, Katherine R. ;
Ivacko, Judith A. ;
Andrews, Ena M. ;
Ferriero, Donna M. ;
Ment, Laura R. ;
Silverstein, Faye S. .
PEDIATRIC NEUROLOGY, 2007, 37 (02) :85-90
[6]   Pyridoxine-dependent and pyridoxine-responsive seizures [J].
Baxter, P .
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2001, 43 (06) :416-420
[7]   Effects of seizures on developmental processes in the immature brain [J].
Ben-Ari, Yehezkel ;
Holmes, Gregory L. .
LANCET NEUROLOGY, 2006, 5 (12) :1055-1063
[8]   Synchronized network activity in developing rat hippocampus involves regional hyperpolarization-activated cyclic nucleotide-gated (HCN) channel function [J].
Bender, RA ;
Galindo, R ;
Mameli, M ;
Gonzalez-Vega, R ;
Valenzuela, CF ;
Baram, TZ .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 22 (10) :2669-2674
[9]   Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1-4 suggests evolving roles in the developing rat hippocampus [J].
Bender, RA ;
Brewster, A ;
Santoro, B ;
Ludwig, A ;
Hofmann, F ;
Biel, M ;
Baram, TZ .
NEUROSCIENCE, 2001, 106 (04) :689-698
[10]   NEONATAL HYPOXIA AND EPILEPTIC RISK - A CLINICAL PROSPECTIVE-STUDY [J].
BERGAMASCO, B ;
BENNA, P ;
FERRERO, P ;
GAVINELLI, R .
EPILEPSIA, 1984, 25 (02) :131-136
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