Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study

被引：32

作者：

Christiani, Camilla Jerlang ^{[1
,2
]}

Jepsen, Jens R. M. ^{[1
,2
,3
,4
,5
]}

Thorup, Anne ^{[1
,2
]}

Hemager, Nicoline ^{[1
,2
,3
]}

Ellersgaard, Ditte ^{[1
,2
]}

Spang, Katrine S. ^{[2
,3
]}

Burton, Birgitte K. ^{[2
,3
]}

Gregersen, Maja ^{[1
,2
]}

Sondergaard, Anne ^{[1
,2
]}

Greve, Aja N. ^{[2
,6
]}

Gantriis, Ditte L. ^{[2
,6
]}

Poulsen, Gry ^{[2
,7
]}

Uddin, Md Jamal ^{[2
,7
]}

Seidman, Larry J. ^{[8
]}

Mors, Ole ^{[2
,6
]}

Plessen, Kerstin J. ^{[2
,3
,9
]}

Nordentoft, Merete ^{[1
,2
,10
]}

机构：

[1] Mental Hlth Ctr, Mental Hlth Serv Capital Reg Denmark, Copenhagen, Denmark

[2] Lundbeck Fdn Initiat Integrat Psychiat Res, Aarhus, Denmark

[3] Child & Adolescent Mental Hlth Ctr, Mental Hlth Serv Capital Reg Denmark, Copenhagen, Denmark

[4] Ctr Neuropsychiat Schizophrenia Res, Copenhagen, Denmark

[5] Ctr Clin Intervent & Neuropsychiat Schizophrenia, Mental Hlth Serv Capital Reg Denmark, Copenhagen, Denmark

[6] Aarhus Univ Hosp, Psychosis Res Unit, Aarhus, Denmark

[7] Univ Copenhagen, Dept Publ Hlth, Sect Biostat, Copenhagen, Denmark

[8] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Psychiat, Boston, MA 02115 USA

[9] Univ Hosp Lausanne, Dept Psychiat, Serv Child & Adolescent Psychiat, Lausanne, Switzerland

[10] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark

来源：

SCHIZOPHRENIA BULLETIN | 2019年 / 45卷 / 06期

关键词：

neurodevelopment; theory of mind; facial affect identification; language; social functioning; offspring; CLINICAL HIGH-RISK; GENETIC RISK; MULTIPLE IMPUTATION; EXECUTIVE FUNCTION; MENTAL STATES; YOUNG-ADULTS; CHILDHOOD; YOUTH; METAANALYSIS; ADOLESCENTS;

D O I：

10.1093/schbul/sbz001

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: To characterize social cognition, language, and social behavior as potentially shared vulnerability markers in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP). Methods: The Danish High-Risk and Resilience Study VIA7 is a multisite population-based cohort of 522 7-year-old children extracted from the Danish registries. The population-based controls were matched to the FHR-SZ children on age, sex, and municipality. The FHR-BP group followed same inclusion criteria. Data were collected blinded to familial high-risk status. Outcomes were social cognition, language, and social behavior. Results: The analysis included 202 FHR-SZ children (girls: 46%), 120 FHR-BP children (girls: 46.7%), and 200 controls (girls: 46.5%). FHR-SZ children displayed significant deficits in language (receptive: d = -0.27, P = .006; pragmatic: d = -0.51, P < .001), social responsiveness (d = -0.54, P < .001), and adaptive social functioning (d = -0.47, P < .001) compared to controls after Bonferroni correction. Compared to FHR-BP children, FHR-SZ children performed significantly poorer on adaptive social functioning (d = -0.29, P = .007) after Bonferroni correction. FHR-BP and FHR-SZ children showed no significant social cognitive impairments compared to controls after Bonferroni correction. Conclusion: Language, social responsiveness, and adaptive social functioning deficits seem associated with FHR-SZ but not FHR-BP in this developmental phase. The pattern of results suggests adaptive social functioning impairments may not be shared between FHR-BP and FHR-SZ in this developmental phase and thus not reflective of the shared risk factors for schizophrenia and bipolar disorder.

引用

页码：1218 / 1230

页数：13

共 72 条

[71] Profiles of executive function in parents and siblings of individuals with autism spectrum disorders
Wong, D.
Maybery, M.
Bishop, D. V. M.
Maley, A.
Hallmayer, J.
[J]. GENES BRAIN AND BEHAVIOR, 2006, 5 (08) : 561 - 576
[72] Wray Naomi R., 2012, Frontiers in Genetics, V3, P118, DOI 10.3389/fgene.2012.00118

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