Regulation and biological activities of the autotaxin-LPA axis

被引：306

作者：

van Meeteren, Laurens A. ^{[1
]}

Moolenaar, Wouter H. ^{[1
]}

机构：

[1] Netherlands Canc Inst, Ctr Biomed Genet, Div Cellular Biochem, NL-1066 CX Amsterdam, Netherlands

来源：

PROGRESS IN LIPID RESEARCH | 2007年 / 46卷 / 02期

关键词：

autotaxin; lysophosphatidic acid; phospholipase D; nucleotide pyrophosphatase/phosphodiesterase; G protein-coupled receptor;

D O I：

10.1016/j.plipres.2007.02.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autotaxin (ATX), or nucleotide pyrophosphatase/phosphodiesterase 2 (NPP2), is an exo-enzyme originally identified as a tumor cell autocrine motility factor. ATX is unique among the NPPs in that it primarily functions as a lysophospholipase D, converting lysophosphatidy1choline into the lipid mediator lysophosphatidic acid (LPA). LPA acts on specific G protein-coupled receptors to elicit a wide range of cellular responses, ranging from cell proliferation and migration to neurite remodeling and cytokine production. While LPA signaling has been studied extensively over the last decade, we are only now beginning to explore the properties and biological importance of ATX as the major LPA-producing phospholipase. In this review, we highlight recent advances in our understanding of the ATX-LPA axis, giving first an update on LPA action and then focusing on ATX, in particular its regulation, its link to cancer and its vital role in vascular development. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：145 / 160

页数：16

共 103 条

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