Retinal stem cells and potential cell transplantation treatments

被引：13

作者：

Lin, Tai-Chi ^{[1
,2
]}

Hsu, Chih-Chien ^{[1
,2
]}

Chien, Ke-Hung ^{[3
,4
]}

Hung, Kuo-Hsuan ^{[5
]}

Peng, Chi-Hsien ^{[1
,6
,7
,8
]}

Chen, Shih-Jen ^{[1
,6
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Ophthalmol, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan

[3] Triserv Gen Hosp, Dept Ophthalmol, Taipei, Taiwan

[4] Natl Yang Ming Univ, Inst Pharmacol, Taipei 112, Taiwan

[5] Natl Yang Ming Univ Hosp, Dept Ophthalmol, Yilan, Taiwan

[6] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[7] Shin Kong Wu Ho Su Mem Hosp, Dept Ophthalmol, Taipei, Taiwan

[8] Fu Jen Catholic Univ, Taipei, Taiwan

来源：

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION | 2014年 / 77卷 / 11期

关键词：

ciliary marginal zones; embryonic stem cells; induced pluripotent stem cells; retinal diseases; stem cells; IN-VITRO DIFFERENTIATION; NEURAL PROGENITOR CELLS; MARROW-DERIVED CELLS; ADULT HUMAN RETINA; MESENCHYMAL STEM; EPITHELIAL-CELLS; MULLER GLIA; VISUAL FUNCTION; C-MYC; REGENERATION;

D O I：

10.1016/j.jcma.2014.08.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The retina, histologically composed of ten delicate layers, is responsible for light perception and relaying electrochemical signals to the secondary neurons and visual cortex. Retinal disease is one of the leading clinical causes of severe vision loss, including age-related macular degeneration, Stargardt's disease, and retinitis pigmentosa. As a result of the discovery of various somatic stem cells, advances in exploring the identities of embryonic stem cells, and the development of induced pluripotent stem cells, cell transplantation treatment for retinal diseases is currently attracting much attention. The sources of stem cells for retinal regeneration include endogenous retinal stem cells (e.g., neuronal stem cells, Muller cells, and retinal stem cells from the ciliary marginal zone) and exogenous stem cells (e.g., bone mesenchymal stem cells, adipose-derived stem cells, embryonic stem cells, and induced pluripotent stem cells). The success of cell transplantation treatment depends mainly on the cell source, the timing of cell harvesting, the protocol of cell induction/transplantation, and the microenvironment of the recipient's retina. This review summarizes the different sources of stem cells for regeneration treatment in retinal diseases and surveys the more recent achievements in animal studies and clinical trials. Future directions and challenges in stem cell transplantation are also discussed. Copyright (C) 2014 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.

引用

页码：556 / 561

页数：6

共 65 条

[1] Identification of neural progenitors in the adult mammalian eye [J].

Ahmad, I ;

Tang, L ;

Pham, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 270 (02) :517-521

[2] In vitro analysis of a mammalian retinal progenitor that gives rise to neurons and glia [J].

Ahmad, I ;

Dooley, CM ;

Thoreson, WB ;

Rogers, JA ;

Afiat, S .

BRAIN RESEARCH, 1999, 831 (1-2) :1-10

[3] Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes [J].

Alvarez-Dolado, M ;

Pardal, R ;

Garcia-Vardugo, JM ;

Fike, JR ;

Lee, HO ;

Pfeffer, K ;

Lois, C ;

Morrison, SJ ;

Alvarez-Buylla, A .

NATURE, 2003, 425 (6961) :968-973

[4] Repair of the degenerate retina by photoreceptor transplantation [J].

Barber, Amanda C. ;

Hippert, Claire ;

Duran, Yanai ;

West, Emma L. ;

Bainbridge, James W. B. ;

Warre-Cornish, Katherine ;

Luhmann, Ulrich F. O. ;

Lakowski, Jorn ;

Sowden, Jane C. ;

Ali, Robin R. ;

Pearson, Rachael A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (01) :354-359

[5] Late-stage neuronal progenitors in the retina are radial Muller glia that function as retinal stem cells [J].

Bernardos, Rebecca L. ;

Barthel, Linda K. ;

Meyers, Jason R. ;

Raymond, Pamela A. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (26) :7028-7040

[6] A novel in vitro retinal differentiation model by co-culturing adult human bone marrow stem cells with retinal pigmented epithelium cells [J].

Chiou, SH ;

Kao, CL ;

Peng, CH ;

Chen, SJ ;

Tarng, YW ;

Ku, HH ;

Chen, YC ;

Shyr, YM ;

Liu, RS ;

Hsu, CJ ;

Yang, DM ;

Hsu, WM ;

Kuo, CD ;

Lee, CH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 326 (03) :578-585

[7] Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells [J].

Cicero, Samantha A. ;

Johnson, Dianna ;

Reyntjens, Steve ;

Frase, Sharon ;

Connell, Samuel ;

Chow, Lionel M. L. ;

Baker, Suzanne J. ;

Sorrentino, Brian P. ;

Dyer, Michael A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (16) :6685-6690

[8] Facile isolation and the characterization of human retinal stem cells [J].

Coles, BLK ;

Angénieux, B ;

Inoue, T ;

Del Rio-Tsonis, K ;

Spence, JR ;

McInnes, RR ;

Arsenijevic, Y ;

van der Kooy, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15772-15777

[9]

Du YQ, 2010, MOL VIS, V16, P2680

[10] Stem Cells as Tools in Regenerative Therapy for Retinal Degeneration [J].

Enzmann, Volker ;

Yolcu, Esma ;

Kaplan, Henry J. ;

Ildstad, Suzanne T. .

ARCHIVES OF OPHTHALMOLOGY, 2009, 127 (04) :563-571

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