Targeting PI3K-AKT/mTOR signaling in the prevention of autism

被引：90

作者：

Sharma, Aarti ^{[1
]}

Mehan, Sidharth ^{[1
]}

机构：

[1] ISF Coll Pharm, Dept Pharmacol, Neuropharmacol Div, Moga 142001, Punjab, India

来源：

NEUROCHEMISTRY INTERNATIONAL | 2021年 / 147卷

关键词：

Autism; PI3K-AKT; mTOR; Apoptosis; Serotonergic degeneration; Genetic dysfunction; MITOCHONDRIAL DYSFUNCTION; SYNAPTIC PLASTICITY; HUNTINGTONS-DISEASE; TUBEROUS SCLEROSIS; MAMMALIAN TARGET; MOUSE MODEL; PHOSPHATIDYLINOSITOL; 3-KINASE; SPECTRUM DISORDERS; THERAPEUTIC TARGET; PROTEIN-SYNTHESIS;

D O I：

10.1016/j.neuint.2021.105067

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism for mammalian enzyme-related receptors in transducing signals or biological processes such as cell development, differentiation, cell survival, protein synthesis, and metabolism. Upregulation of the PI3K-AKT/mTOR signaling pathway involves many human brain abnormalities, including autism and other neurological dysfunctions. Autism is a neurodevelopmental disorder associated with behavior and psychiatric illness. This research-based review discusses the functional relationship between the neuropathogenic factors associated with PI3K-AKT/mTOR signaling pathway. Ultimately causes autism-like conditions associated with genetic alterations, neuronal apoptosis, mitochondrial dysfunction, and neuroinflammation. Therefore, inhibition of the PI3K-AKT/mTOR signaling pathway may have an effective therapeutic value for autism treatment. The current review also summarizes the involvement of PI3K-AKT/mTOR signaling pathway inhibitors in the treatment of autism and other neurodegenerative disorders.

引用

页数：15

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