The influence of urinary flow rate on mercury excretion in children

被引：11

作者：

Trachtenberg, Felicia ^{[1
]}

Barregard, Lars ^{[2
]}

McKinlay, Sonja ^{[1
]}

机构：

[1] New England Res Inst, Watertown, MA 02472 USA

[2] Sahlgrenska Univ Hosp & Acad, Dept Occupat & Environm Med, Gothenburg, Sweden

来源：

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY | 2010年 / 24卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Mercury; Urinary flow rate; Children; HEAVY-METALS; CREATININE EXCRETION; ADJUSTMENT; EXPOSURE; PLASMA;

D O I：

10.1016/j.jtemb.2009.06.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Project: There is limited literature concerning the effect of urinary flow rate on mercury excretion at low-level exposure. The aim of the present study is to examine the influence of urinary flow rate on mercury excretion in children. Also of interest is the influence of flow rate on creatinine excretion and creatinine-corrected mercury, which arisearises with spot urine samples. Procedure: A substudy of the New England Children's Amalgam Trial collected pairs of urine samples from children aged 10-16 years: a timed overnight collection and a spot daytime sample collected the following day. These samples were analyzed for mercury and creatinine concentration. Regression analysis was used to model the effect of urinary flow rate in the timed overnight samples. A paired t-test compared concentrations and creatinine-corrected mercury between overnight and daytime samples. Results: Creatinine excretion rate (mg/h) increased significantly with urinary flow rate (mL/h), whereas creatinine concentration (g/L) decreased with flow rate. We found a non-significant increase in mercury excretion rate (ng/h) with flow rate, and mercury concentration decreased with flow rate. Mercury and creatinine concentrations were significantly higher in the overnight compared to daytime samples. For creatinine-corrected mercury, no significant impact of urinary flow rate was found. Conclusions: Although the creatinine excretion rate, and probably the mercury excretion rate, increased with urinary flow rate, the mercury/creatinine ratio seemed relatively unaffected by urinary flow rate. (C) 2009 Elsevier GmbH. All rights reserved.

引用

页码：31 / 35

页数：5

共 16 条

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