New anti-trypanosomal active prenylated compounds from African propolis

被引：25

作者：

Almutairi, Sultan ^{[1
]}

Eapen, Ben ^{[1
]}

Chundi, Sai Maneesha ^{[1
]}

Akhalil, Adnan ^{[1
]}

Siheri, Weam ^{[1
]}

Clements, Carol ^{[1
]}

Fearnley, James ^{[2
]}

Watson, David G. ^{[1
]}

Edrada-Ebel, RuAngelie ^{[1
]}

机构：

[1] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0RE, Lanark, Scotland

[2] Apiceut Res Ctr, Whitby YO21 3DA, N Yorkshire, England

来源：

PHYTOCHEMISTRY LETTERS | 2014年 / 10卷

关键词：

Propolis; Geranylated stilbene; Prenylated propolone; Antitrypanosomal activity; NMR; HRESIMS; BIOLOGICAL-PROPERTIES; HONEY-BEES; IN-VITRO; STILBENES;

D O I：

10.1016/j.phytol.2014.07.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The secondary metabolite composition of propolis has always been corroborated on the vegetation surrounding the bee hive. The plants chosen by the bees seem to exhibit activity to protect the hive from the surrounding environmental pressures which include protozoal attack. Two new stilbene compounds were isolated from Ghanian propolis which were formed either via geranylation or prenylation. These compounds exhibited moderate activity against Trypanosoma brucei brucei. While a new phlorogucinonone analogue was isolated from a Cameroon propolis that was found to possess high potency comparable to that of suramin. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：35 / 39

页数：5

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