Associations between plasma neurofilament light, in vivo brain pathology, and cognition in non-demented individuals with autosomal-dominant Alzheimer's disease

被引：17

作者：

Guzman-Velez, Edmarie ^{[1
]}

Zetterberg, Henrik ^{[2
,3
,4
,5
]}

Fox-Fuller, Joshua T. ^{[1
,6
]}

Vila-Castelar, Clara ^{[1
]}

Sanchez, Justin S. ^{[1
]}

Baena, Ana ^{[7
]}

Garcia-Ospina, Gloria ^{[7
]}

Aguillon, David ^{[7
]}

Pardilla-Delgado, Enmanuelle ^{[1
]}

Gatchel, Jennifer R. ^{[1
,8
]}

Sperling, Reisa A. ^{[1
,9
]}

Johnson, Keith ^{[1
,9
]}

Reiman, Eric M. ^{[10
,11
,12
,13
]}

Blennow, Kaj ^{[2
,3
]}

Lopera, Francisco ^{[7
]}

Quiroz, Yakeel T. ^{[1
,7
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA

[2] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[3] Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Molndal Campus, Molndal, Sweden

[4] UCL, UK Dementia Res Inst, London, England

[5] UCL Inst Neurol, Dept Neurodegenerat Dis, London, England

[6] Boston Univ, Dept Psychol & Brain Sci, Boston, MA 02215 USA

[7] Univ Antioquia, Grp Neurociencias Antioquia, Medellin, Colombia

[8] McLean Hosp, Div Geriatr Psychiat & Psychiat Neurotherapeut, 115 Mill St, Belmont, MA 02178 USA

[9] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[10] Banner Alzheimers Inst, Phoenix, AZ USA

[11] Univ Arizona, Phoenix, AZ USA

[12] Arizona State Univ, Phoenix, AZ USA

[13] Translat Genom Res Inst, Phoenix, AZ USA

来源：

ALZHEIMERS & DEMENTIA | 2021年 / 17卷 / 05期

基金：

英国医学研究理事会;

关键词：

Alzheimer' s disease; biomarkers; NfL; pathology; preclinical; presenilin‐ 1; AMYLOID-BETA; CHAIN; TAU; PET; NEURODEGENERATION; SEVERITY; MARKERS;

D O I：

10.1002/alz.12248

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Neurofilament light (NfL) is a promising biomarker of early neurodegeneration in Alzheimer's disease (AD). We examined whether plasma NfL was associated with in vivo amyloid beta and tau, and cognitive performance in non-demented presenilin-1 (PSEN1) E280A mutation carriers. Methods Twenty-five mutation carriers and 19 non-carriers (age range: 28 to 49 years) were included in this study. Participants underwent 11C Pittsburgh compound B (PiB)-PET (positron emission tomography), flortaucipir-PET, blood sampling, and cognitive testing. Results Mutation carriers exhibited higher plasma NfL levels than non-carriers. In carriers, higher NfL levels were related to greater regional tau burden and worse cognition, but not amyloid beta load. When we adjusted for age, a proxy of disease progression, elevated plasma NfL levels were only correlated with worse memory recall. Conclusions Findings support an association between plasma NfL, cognition, and tau pathology in non-demented individuals at genetic risk for developing AD dementia. Plasma NfL may be useful for selecting individuals at increased risk and tracking disease progression in AD.

引用

页码：813 / 821

页数：9

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