Management considerations for childhood-onset systemic lupus erythematosus patients and implications on therapy

被引：36

作者：

Silva, Clovis Artur ^{[1
,2
]}

Aikawa, Nadia Emi ^{[1
,2
]}

Rodrigues Pereira, Rosa Maria ^{[2
]}

Arruda Campos, Lucia Maria ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Med, Pediat Rheumatol Unit, Ave Dr Eneas Carvalho Aguiar,647 Cerqueira Cesar, BR-05403000 Sao Paulo, Brazil

[2] Univ Sao Paulo, Fac Med, Div Rheumatol, BR-05403000 Sao Paulo, Brazil

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2016年 / 12卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

Childhood-onset systemic lupus erythematosus; immunosuppressive; infection; vaccination; dyslipidemia; cancer; vitamin D; osteoporosis; exercise; fertility; CHRONIC INFLAMMATORY DISEASES; CLASSIFICATION CRITERIA; RHEUMATIC-DISEASES; DOUBLE-BLIND; MYCOPHENOLIC-ACID; MAJOR INFECTIONS; OVARIAN RESERVE; YOUNG-PATIENTS; PEDIATRIC SLE; VITAMIN-D;

D O I：

10.1586/1744666X.2016.1123621

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Childhood-onset systemic lupus erythematosus (cSLE) is a chronic inflammatory and autoimmune disease that may involve various organs and systems. This narrative review focuses on the recent evidence relating to cSLE management. The general management considerations of cSLE patients require the use of validated classification criteria, disease and health-related quality of life tools evaluation, as well as assessments of lupus nephritis biomarkers and cSLE quality indicators. The drug treatment for cSLE patients includes general supportive care and immunosuppressive therapy. Important implications on cSLE therapy are also updated such as infection, vaccination, infertility, pregnancy, contraception, dyslipidemia, physical activity, cancer, bone health, drug pharmacokinetics, adherence, academic outcomes, transition to adult care and cumulative organ damage.

引用

页码：301 / 313

页数：13

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