Endothelium, venous thromboembolism and ischaemic cardiovascular events

被引：68

作者：

Gresele, Paolo ^{[1
]}

Momi, Stefania ^{[1
]}

Migliacci, Rino ^{[2
]}

机构：

[1] Univ Perugia, Dept Internal Med, Div Internal & Cardiovasc Med, I-06126 Perugia, Italy

[2] Osped Valdichiana S Margherita, Div Internal Med, Cortona, Italy

来源：

THROMBOSIS AND HAEMOSTASIS | 2010年 / 103卷 / 01期

关键词：

Arterial thrombosis; atherothrombosis; venous thrombosis; endothelial cells; nitric oxide/NO; DEEP-VEIN THROMBOSIS; PARTICULATE AIR-POLLUTION; PLASMA FIBRONECTIN LEVELS; RISK-FACTORS; SYSTEMIC INFLAMMATION; MYOCARDIAL-INFARCTION; DEPENDENT DILATATION; PULMONARY-EMBOLISM; SAPHENOUS-VEIN; ACUTE INFECTION;

D O I：

10.1160/TH09-08-0562

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The association between venous thromboembolism and arterial thrombosis has emerged as consistent clinical observation in the last few years. While several experimental, epidemiological and pharmacologic studies support this association, the initial pathophysiological mechanism linking these two clinical conditions remains to be established. This review discusses the pathophysiological bases and a number of experimental and clinical observations suggesting that the common link between venous thromboembolism and arterial thrombosis is represented by a dysfunctional endothelium.

引用

页码：56 / 61

页数：6

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