Thyroid gland invasion in advanced squamous cell carcinoma of the larynx and hypopharynx

被引:16
作者
Mangussi-Gomes, Joao [1 ]
Danelon-Leonhardt, Fernando [1 ]
Moussalem, Guilherme Figner [1 ]
Ahumada, Nicolas Galat [1 ]
Oliveira, Cleydson Lucena [1 ]
Hojaij, Flavio Carneiro [1 ,2 ]
机构
[1] Univ Fed Sao Paulo, Dept Otorrinolaringol Cirurgia Cabeca & Pescoco, Sao Paulo, SP, Brazil
[2] Univ Sao Paulo, Lab Pesquisas Clin LIM 32, Sao Paulo, SP, Brazil
关键词
Squamous cell carcinoma; Larynx; Hypopharynx; Laryngectomy; Pharyngectomy; Thyroidectomy; MANAGEMENT; INVOLVEMENT;
D O I
10.1016/j.bjorl.2016.03.019
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Introduction: Squamous cell carcinoma of the larynx and hypopharynx has the potential to invade the thyroid gland. Despite this risk, the proposition of either partial or total thyroidectomy as part of the surgical treatment of all such cases remains controversial. Objectives: To evaluate the frequency of invasion of the thyroid gland in patients with advanced laryngeal or hypopharyngeal squamous cell carcinoma submitted to total laryngectomy or pharyngolaryngectomy and thyroidectomy; to determine whether clinic-pathological characteristics can predict glandular involvement. Methods: A retrospective case series with chart review, from January 1998 to July 2013, was undertaken in a tertiary care university medical center. An inception cohort of 83 patients with larynx/hypopharynx squamous cell carcinoma was considered. All patients had advanced stage disease (clinically T3-T4) and underwent total laryngectomy or total pharyngolaryngectomy in association with thyroidectomy. Adjuvant therapy was indicated when tumor or neck conditions required. Frequency of thyroid cartilage invasion was calculated; univariate and multivariate analysis of demographic, clinical and pathological characteristics associated with cartilage invasion were performed. Results: The overall frequency of invasion of the thyroid gland was 18.1%. Glandular involvement was associated with invasion of the following structures: anterior commissure (odds ratio = 5.13; 95% confidence interval 1.07-24.5), subglottis (odds ratio = 12.44; 95% confidence interval 1.55-100.00) and cricoid cartilage (odds ratio = 15.95; 95% confidence interval 4.23-60.11). Conclusions: Invasion of the thyroid gland is uncommon in the context of laryngopharyngeal squamous cell carcinoma. Clinical and pathological features such as invasion of the anterior commissure, subglottis and cricoid cartilage are more associated with glandular invasion. (C) 2017 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.
引用
收藏
页码:269 / 275
页数:7
相关论文
共 50 条
[41]   Primary aspergillosis of the larynx and squamous cell carcinoma [J].
Beust, L ;
Godey, B ;
Le Gall, F ;
Grollier, R ;
Le Clech, G .
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 1998, 107 (10) :851-854
[42]   Squamous cell carcinoma of the larynx in a Shetland pony [J].
van den Wollenberg, L ;
van den Belt, AJM ;
van der Kolk, JH .
EQUINE VETERINARY EDUCATION, 2002, 14 (02) :60-62
[43]   Squamous cell carcinoma of the thyroid gland: primary or secondary disease? [J].
Syed, M. I. ;
Stewart, M. ;
Syed, S. ;
Dahill, S. ;
Adams, C. ;
McLellan, D. R. ;
Clark, L. J. .
JOURNAL OF LARYNGOLOGY AND OTOLOGY, 2011, 125 (01) :3-9
[44]   The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx:: N0 versus N+ [J].
Mayland, MK ;
Sessions, DG ;
Lenox, J .
LARYNGOSCOPE, 2005, 115 (04) :629-639
[45]   Basaloid squamous cell carcinoma of the hypopharynx: an analysis of 213 cases [J].
Chubo Xie ;
Jing Liao ;
Chunxia Huang ;
Fanqin Wei ;
Tianrun Liu ;
Weiping Wen ;
Wei Sun .
European Archives of Oto-Rhino-Laryngology, 2022, 279 :2099-2107
[46]   INTENSITY-MODULATED RADIOTHERAPY FOR LOCALLY ADVANCED CANCERS OF THE LARYNX AND HYPOPHARYNX [J].
Daly, Megan E. ;
Le, Quynh-Thu ;
Jain, Anshu K. ;
Maxim, Peter G. ;
Hsu, Annie ;
Loo, Billy W., Jr. ;
Kaplan, Michael J. ;
Fischbein, Nancy J. ;
Colevas, A. Dimitrios ;
Pinto, Harlan ;
Chang, Daniel T. .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2011, 33 (01) :103-111
[47]   IMPACT AND MANAGEMENT OF AIRWAY OBSTRUCTION IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE LARYNX [J].
Chu, Pen-Yuan ;
Lee, Tsung-Lun ;
Chang, Shyue-Yih .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2011, 33 (01) :98-102
[48]   Basaloid squamous cell carcinoma of the larynx [J].
Akyol, MU ;
Seckin, S ;
Akbayrak, L ;
Ozdem, C .
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 1995, 252 (08) :485-487
[49]   Functional Outcomes and Complications After Salvage Total Laryngectomy for Residual, Recurrent, and Second Primary Squamous Cell Carcinoma of the Larynx and Hypopharynx: A Multicenter Retrospective Cohort Study [J].
Meulemans, Jeroen ;
Demarsin, Hannelore ;
Debacker, Jens ;
Batailde, Gael ;
Mennes, Tillo ;
Laenen, Annouschka ;
Goeleven, Ann ;
Neyt, Peter ;
Vanclooster, Christophe ;
Vauterin, Tom ;
Delaere, Pierre ;
Huvenne, Wouter ;
Vander Poorten, Vincent .
FRONTIERS IN ONCOLOGY, 2020, 10
[50]   SQUAMOUS-CELL CARCINOMA OF THE LARYNX AND PHARYNX IN HORSES [J].
JONES, DL .
CORNELL VETERINARIAN, 1994, 84 (01) :15-24