RORγt inhibitors suppress TH17 responses in inflammatory arthritis and inflammatory bowel disease

被引：30

作者：

de Wit, Jelle ^{[1
]}

Al-Mossawi, M. Hussein ^{[1
]}

Huehn, Michael H. ^{[2
]}

Arancibia-Carcamo, Carolina V. ^{[2
]}

Doig, Karen ^{[1
]}

Kendrick, Benjamin ^{[1
]}

Gundle, Roger ^{[1
]}

Taylor, Peter ^{[3
]}

Mcclanahan, Terri ^{[4
]}

Murphy, Erin ^{[4
]}

Zhang, Hongjun ^{[5
]}

Barr, Ken ^{[5
]}

Miller, J. Richard ^{[5
]}

Hu, Xiao ^{[5
]}

Aicher, Thomas D. ^{[6
]}

Morgan, Rodney W. ^{[6
]}

Glick, Gary D. ^{[7
]}

Zaller, Dennis ^{[5
]}

Correll, Craig ^{[5
]}

Powrie, Fiona ^{[2
,8
]}

Bowness, Paul ^{[1
,3
]}

机构：

[1] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Translat Gastroenterol Unit,Expt Med Div, Oxford OX3 9DU, England

[3] Univ Oxford, Nuffield Orthopaed Ctr, Natl Inst Hlth Res, Musculoskeletal Biomed Res Unit, Oxford, England

[4] Merck Res Labs, Palo Alto, CA USA

[5] Merck Res Labs, Boston, MA USA

[6] Lycera Corp, Ann Arbor, MI USA

[7] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[8] Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2016年 / 137卷 / 03期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

EXPRESSION; RECEPTOR; CELLS; DIFFERENTIATION;

D O I：

10.1016/j.jaci.2015.09.048

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

[No abstract available]

引用

页码：960 / 963

页数：12

共 14 条

[1] Murine nasal septa for respiratory epithelial air-liquid interface cultures [J].

Antunes, Marcelo B. ;

Woodworth, Bradford A. ;

Bhargave, Geeta ;

Xiong, Guoxiang ;

Aguilar, Jorge L. ;

Ratner, Adam J. ;

Kreindler, James L. ;

Rubenstein, Ronald C. ;

Cohen, Noam A. .

BIOTECHNIQUES, 2007, 43 (02) :195-+

[2] Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements [J].

Barnden, MJ ;

Allison, J ;

Heath, WR ;

Carbone, FR .

IMMUNOLOGY AND CELL BIOLOGY, 1998, 76 (01) :34-40

[3] Expression of Toll-like Receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis [J].

Fransson, Mattias ;

Benson, Mikael ;

Erjefalt, Jonas S. ;

Jansson, Lennart ;

Uddman, Rolf ;

Bjornsson, Sven ;

Cardell, Lars-Olaf ;

Adner, Mikael .

RESPIRATORY RESEARCH, 2007, 8 (1)

[4] Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study [J].

Genovese, Mark C. ;

Durez, Patrick ;

Richards, Hanno B. ;

Supronik, Jerzy ;

Dokoupilova, Eva ;

Mazurov, Vadim ;

Aelion, Jacob A. ;

Lee, Sang-Heon ;

Codding, Christine E. ;

Kellner, Herbert ;

Ikawa, Takashi ;

Hugot, Sophie ;

Mpofu, Shephard .

ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (06) :863-869

[5] Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial [J].

Hueber, Wolfgang ;

Sands, Bruce E. ;

Lewitzky, Steve ;

Vandemeulebroecke, Marc ;

Reinisch, Walter ;

Higgins, Peter D. R. ;

Wehkamp, Jan ;

Feagan, Brian G. ;

Yao, Michael D. ;

Karczewski, Marek ;

Karczewski, Jacek ;

Pezous, Nicole ;

Bek, Stephan ;

Bruin, Gerard ;

Mellgard, Bjoern ;

Berger, Claudia ;

Londei, Marco ;

Bertolino, Arthur P. ;

Tougas, Gervais ;

Travis, Simon P. L. .

GUT, 2012, 61 (12) :1693-1700

[6] Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity [J].

Huh, Jun R. ;

Leung, Monica W. L. ;

Huang, Pengxiang ;

Ryan, Daniel A. ;

Krout, Michael R. ;

Malapaka, Raghu R. V. ;

Chow, Jonathan ;

Manel, Nicolas ;

Ciofani, Maria ;

Kim, Sangwon V. ;

Cuesta, Adolfo ;

Santori, Fabio R. ;

Lafaille, Juan J. ;

Xu, H. Eric ;

Gin, David Y. ;

Rastinejad, Fraydoon ;

Littman, Dan R. .

NATURE, 2011, 472 (7344) :486-490

[7] The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells [J].

Ivanov, Ivaylo I. ;

McKenzie, Brent S. ;

Zhou, Liang ;

Tadokoro, Carlos E. ;

Lepelley, Alice ;

Lafaille, Juan J. ;

Cua, Daniel J. ;

Littman, Dan R. .

CELL, 2006, 126 (06) :1121-1133

[8] IL-17 and Th17 Cells [J].

Korn, Thomas ;

Bettelli, Estelle ;

Oukka, Mohamed ;

Kuchroo, Vijay K. .

ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :485-517

[9] New IBD genetics: common pathways with other diseases [J].

Lees, C. W. ;

Barrett, J. C. ;

Parkes, M. ;

Satsangi, J. .

GUT, 2011, 60 (12) :1739-1753

[10] Brodalumab, an Anti-IL17RA Monoclonal Antibody, in Psoriatic Arthritis [J].

Mease, Philip J. ;

Genovese, Mark C. ;

Greenwald, Maria W. ;

Ritchlin, Christopher T. ;

Beaulieu, Andre D. ;

Deodhar, Atul ;

Newmark, Richard ;

Feng, JingYuan ;

Erondu, Ngozi ;

Nirula, Ajay .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (24) :2295-2306

← 1 2 →