Outpatient desensitization in selected patients with platinum hypersensitivity reactions

被引：26

作者：

O'Malley, David M. ^{[1
]}

Vetter, Monica Hagan ^{[1
]}

Cohn, David E. ^{[1
]}

Khan, Ambar ^{[2
]}

Hays, John L. ^{[3
]}

机构：

[1] Ohio State Univ, Coll Med, Dept Gynecol & Obstet, Div Gynecol Oncol, Columbus, OH 43220 USA

[2] Ohio State Univ, Comprehens Canc Ctr, Dept Pharm, Columbus, OH 43220 USA

[3] Ohio State Univ, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USA

来源：

GYNECOLOGIC ONCOLOGY | 2017年 / 145卷 / 03期

关键词：

Carboplatin; Hypersensitivity reactions; Desensitization; CARBOPLATIN HYPERSENSITIVITY; OVARIAN-CANCER; RISK-STRATIFICATION; CLINICAL-FEATURES; OXALIPLATIN; ALLERGY; EXPERIENCE; MANAGEMENT; CISPLATIN; MALIGNANCIES;

D O I：

10.1016/j.ygyno.2017.03.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Platinum-based chemotherapies are a standard treatment for both initial and recurrent gynecologic cancers. Given this widespread use, it is important to be aware of the features of platinum hypersensitivity reactions and the subsequent treatment of these reactions. There is also increasing interest in the development of desensitization protocols to allow patients with a history of platinum hypersensitivity to receive further platinum based therapy. In this review, we describe the management of platinum hypersensitivity reactions and the desensitization protocols utilized at our institution. We also describe the clinical categorizations utilized to triage patients to appropriate desensitization protocols. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：603 / 610

页数：8

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