New Azaphilones from Nigrospora oryzae Co-Cultured with Beauveria bassiana

被引：24
作者：
Zhang, Zhuo-Xi [1 ]
Yang, Xue-Qiong [1 ]
Zhou, Qing-Yan [1 ]
Wang, Bang-Yan [1 ]
Hu, Ming [1 ]
Yang, Ya-Bin [1 ]
Zhou, Hao [1 ]
Ding, Zhong-Tao [1 ]
机构：
[1] Yunnan Univ, Sch Chem Sci & Technol, Funct Mol Anal & Biotransformat Key Lab Univ Yunn, 2st Cuihu North Rd, Kunming 650091, Yunnan, Peoples R China
来源：
MOLECULES | 2018年 / 23卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Nigrospora oryzae; Beauveria bassiana; co-culture; azaphilone; antifungal selectivity; NO inhibitory activity; FUNGUS; FERMENTATION; DERIVATIVES;
D O I：
10.3390/molecules23071816
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, the co-culture of Nigrospora oryzae and Beauveria bassiana, the endophytes in the seeds of Dendrobium officinale, were examined for metabolite diversity. Five new azaphilones were isolated, and their structures were determined by spectral analysis. In terms of azaphilones, compound 2 had an unprecedented skeleton, with a bicyclic oxygen bridge. The antifungal selectivities of the metabolite produced by N. oryzae against its co-culture fungus, B. bassiana, and common pathogens exhibited competitive interaction in this mix-culture. Compounds 1 and 2 showed obvious nitric oxide (NO) inhibitory activity with ratios of 37%, and 39%, respectively, at a concentration of 50 M.
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页数：7
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