CHEMISTRY OF RENIERAMYCINS. 16. STRUCTURE OF 7-DEMETHYLRENIERAMYCIN O (=14α-HYDROXYRENIERAMYCIN S) FROM BLUE SPONGE, XESTOSPONGIA sp.

被引：8

作者：

Saito, Naoki ^{[1
]}

Hiramatsu, Ai ^{[1
]}

Hirade, Hiromi ^{[1
]}

Kubota, Mitsue ^{[1
]}

Toyoshima, Ryoko ^{[1
]}

Fujino, Akiya ^{[1
]}

Sirimangkalakitti, Natchanun ^{[2
]}

Suwanborirux, Khanit ^{[2
]}

Concepcion, Gisela P. ^{[3
]}

机构：

[1] Meiji Pharmaceut Univ, Grad Sch Pharmaceut Sci, 2-522-1 Noshio, Tokyo 2048588, Japan

[2] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Pharmaceut Bot, Ctr Bioact Nat Prod Marine Organisms & Endophyt F, Bangkok 10330, Thailand

[3] Univ Philippines, Marine Sci Inst, Quezon City 1101, Philippines

来源：

HETEROCYCLES | 2017年 / 95卷 / 02期

关键词：

Isoquinoline; Anticancer Activity; Structure Determination; Renieramycin; Structure Transformation; NUDIBRANCH JORUNNA-FUNEBRIS; ISOQUINOLINEQUINONE ALKALOIDS; POTASSIUM CYANIDE; ECTEINASCIDIN; 770; DERIVATIVES; CYTOTOXICITY;

D O I：

10.3987/COM-16-S(S)77

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new renieramycin-type marine natural product was isolated from the blue sponge Xestospongia sp. found in the Philippines and Thailand, and its structure was elucidated to be 7-demethylrenieramycin 0 (= 14 alpha-hydroxyrenieramycin S, 1) by comparing its spectral data with those of renieramycins 0 and S. Exposure of a dichloromethane solution of renieramycin 0 to sunlight gave compound 1 along with renieramycin U. Compound 1 showed weak cytotoxicity to several human cancer cell lines.

引用

页码：748 / 752

页数：5

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