Reduced Mastication Impairs Memory Function

被引:77
作者
Fukushima-Nakayama, Y. [1 ,2 ]
Ono, Takehito [1 ]
Hayashi, M. [1 ]
Inoue, M. [1 ,2 ]
Wake, H. [3 ]
Ono, Takashi [1 ,2 ]
Nakashima, T. [1 ,4 ,5 ]
机构
[1] TMDU, Grad Sch Med & Dent Sci, Dept Cell Signaling, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138549, Japan
[2] TMDU, Grad Sch Med & Dent Sci, Dept Orthodont Sci, Oral Hlth Sci,Bunkyo Ku, Tokyo, Japan
[3] Kobe Univ, Grad Sch Med, Dept Syst Physiol, Chuo Ku, Kobe, Hyogo, Japan
[4] Japan Sci & Technol Agcy JST, Precursory Res Embryon Sci Technol PRESTO, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138549, Japan
[5] Japan Agcy Med Res & Dev, AMED, CREST, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138549, Japan
基金
日本科学技术振兴机构; 日本学术振兴会;
关键词
oral health; growth and development; memory disorders; neurogenesis; synapses; neurotrophic factors; ORAL-HEALTH; TOOTH LOSS; COGNITIVE DYSFUNCTION; SPATIAL MEMORY; GENERAL HEALTH; DENTATE GYRUS; C-FOS; MICE; EXPRESSION; NEURONS;
D O I
10.1177/0022034517708771
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Mastication is an indispensable oral function related to physical, mental, and social health throughout life. The elderly tend to have a masticatory dysfunction due to tooth loss and fragility in the masticatory muscles with aging, potentially resulting in impaired cognitive function. Masticatory stimulation has influence on the development of the central nervous system (CNS) as well as the growth of maxillofacial tissue in children. Although the relationship between mastication and cognitive function is potentially important in the growth period, the cellular and molecular mechanisms have not been sufficiently elucidated. Here, we show that the reduced mastication resulted in impaired spatial memory and learning function owing to the morphological change and decreased activity in the hippocampus. We used an in vivo model for reduced masticatory stimuli, in which juvenile mice were fed with powder diet and found that masticatory stimulation during the growth period positively regulated long-term spatial memory to promote cognitive function. The functional linkage between mastication and brain was validated by the decrease in neurons, neurogenesis, neuronal activity, and brain-derived neurotrophic factor (BDNF) expression in the hippocampus. These findings taken together provide in vivo evidence for a functional linkage between mastication and cognitive function in the growth period, suggesting a need for novel therapeutic strategies in masticatory function-related cognitive dysfunction.
引用
收藏
页码:1058 / 1066
页数:9
相关论文
共 41 条
[31]   Masticatory Deficiency as a Risk Factor for Cognitive Dysfunction [J].
Teixeira, Francisco Bruno ;
Pereira Fernandes, Luanna de Melo ;
Tavares Noronha, Patrycy Assis ;
Raiol dos Santos, Marcio Antonio ;
Gomes-Leal, Walace ;
Ferraz Maia, Cristiane do Socorro ;
Lima, Rafael Rodrigues .
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2014, 11 (02) :209-214
[32]   Modulation of passive avoidance in mice by the 5-HTIA receptor agonist flesinoxan:: Comparison with the benzodiazepine receptor agonist diazepam [J].
Tsuji, M ;
Takeda, H ;
Matsumiya, T .
NEUROPSYCHOPHARMACOLOGY, 2003, 28 (04) :664-674
[33]   Influences of reduced masticatory sensory input from soft-diet feeding upon spatial memory/learning ability in mice [J].
Tsutsui, Keisuke ;
Kaku, Masato ;
Motokawa, Masahide ;
Tohma, Yuiko ;
Kawata, Toshitsugu ;
Fujita, Tadashi ;
Kohno, Shinya ;
Ohtani, Junji ;
Tenjoh, Kaoru ;
Nakano, Mao ;
Kamada, Hiroko ;
Tanne, Kazuo .
BIOMEDICAL RESEARCH-TOKYO, 2007, 28 (01) :1-7
[34]   Role of neurotrophins in central synapse formation and stabilization [J].
Vicario-Abejón, C ;
Owens, D ;
McKay, R ;
Segal, M .
NATURE REVIEWS NEUROSCIENCE, 2002, 3 (12) :965-974
[35]   Oral mixing ability and cognition in elderly persons with dementia: A cross-sectional study [J].
Weijenberg, R. A. F. ;
Lobbezoo, F. ;
Visscher, C. M. ;
Scherder, E. J. A. .
JOURNAL OF ORAL REHABILITATION, 2015, 42 (07) :481-486
[36]   Learning induces long-term potentiation in the hippocampus [J].
Whitlock, Jonathan R. ;
Heynen, Arnold J. ;
Shuler, Marshall G. ;
Bear, Mark F. .
SCIENCE, 2006, 313 (5790) :1093-1097
[37]   Occlusal Disharmony Transiently Impairs Learning and Memory in the Mouse by Increasing Dynorphin A Levels in the Amygdala [J].
Yamada, Kentaro ;
Ono, Yumie ;
Kubo, Kin-ya ;
Yamamoto, Toshiharu ;
Onozuka, Minoru .
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 230 (01) :49-57
[38]   Associations among oral health-related quality of life, subjective symptoms, clinical status, and self-rated oral health in Japanese university students: a cross-sectional study [J].
Yamane-Takeuchi, Mayu ;
Ekuni, Daisuke ;
Mizutani, Shinsuke ;
Kataoka, Kota ;
Taniguchi-Tabata, Ayano ;
Azuma, Tetsuji ;
Furuta, Michiko ;
Tomofuji, Takaaki ;
Iwasaki, Yoshiaki ;
Morita, Manabu .
BMC ORAL HEALTH, 2016, 16
[39]   Effect of tooth loss on spatial memory and TrkB-mRNA levels in rats [J].
Yamazaki, Kaoruko ;
Wakabayashi, Noriyuki ;
Kobayashi, Takuya ;
Suzuki, Tetsuya .
HIPPOCAMPUS, 2008, 18 (06) :542-547
[40]   Memory-dependent c-Fos expression in the nucleus accumbens and extended amygdala following the expression of a conditioned taste aversive in the rat [J].
Yasoshima, Y. ;
Scott, T. R. ;
Yamamoto, T. .
NEUROSCIENCE, 2006, 141 (01) :35-45