Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans

被引：9

作者：

Park, Ji-Young ^{[1
]}

Lim, Su Hwan ^{[1
,2
]}

Kim, Bo Ram ^{[1
]}

Jeong, Hyung Jae ^{[1
]}

Kwon, Hyung-Jun ^{[1
]}

Song, Gyu-Yong ^{[2
]}

Ryu, Young Bae ^{[1
]}

Lee, Woo Song ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Nat Prod Mat Res Ctr, Jeongeup 56212, South Korea

[2] Chungnam Natl Univ, Coll Pharm, 99 Daehak Ro, Daejon 305764, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 14期

基金：

新加坡国家研究基金会;

关键词：

Sialidase; NanA; NanB; Myristica fragrans; Malabaricone C; STREPTOCOCCUS-PNEUMONIAE; VIRULENCE FACTORS; NEURAMINIDASE; COLONIZATION; DISEASE; SEPSIS; CONSTITUENTS; CHILDREN;

D O I：

10.1016/j.bmcl.2017.05.055

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sialidases are key virulence factors that remove sialic acid from host cell surface glycans, thus unmasking receptors to facilitate bacterial adherence and colonization. In this study, we report the isolation and characterization of novel inhibitors of the Streptococcus pneumoniae sialidases NanA, NanB, and NanC from Myristica fragrans seeds. Of the isolated compounds (1-12), malabaricone C showed the most pneumococcal sialidases inhibition (IC50 of 0.3 mu M for NanA, 3.6 mu M for NanB, and 2.9 mu M for NanC). These results suggested that malabaricone C and neolignans could be potential agents for combating S. pneumoniae infection agents. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：3060 / 3064

页数：5

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