Oral Mucositis: Melatonin Gel an Effective New Treatment

被引：39
作者：
Moneim, Ahmed Esmat Abdel [1 ]
Guerra-Librero, Ana [2 ]
Florido, Javier [2 ]
Shen, Ying-Qiang [2 ]
Fernandez-Gil, Beatriz [2 ]
Acuna-Castroviejo, Dario [2 ,3 ,4 ]
Escames, Germaine [2 ,3 ,4 ]
机构：
[1] Helwan Univ, Dept Zool & Entomol, Fac Sci, Cairo 11795, Egypt
[2] Univ Granada, Ctr Invest Biomed, Granada 18016, Spain
[3] Ibs Granada, CIBERfes, Granada 18014, Spain
[4] Complejo Hosp Granada, UGC Lab Clin, Granada 18014, Spain
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 05期
关键词：
mucositis; radiotherapy; chemotherapy; pathophysiology; management; melatonin; LEVEL LASER THERAPY; PINEAL NEUROHORMONE MELATONIN; BONE-MARROW-TRANSPLANTATION; NITRIC-OXIDE SYNTHASE; NECK-CANCER PATIENTS; HELIUM-NEON LASER; RED-BLOOD-CELLS; DOUBLE-BLIND; COLORECTAL-CANCER; INDUCED APOPTOSIS;
D O I：
10.3390/ijms18051003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The current treatment for cervico-facial cancer involves radio and/or chemotherapy. Unfortunately, cancer therapies can lead to local and systemic complications such as mucositis, which is the most common dose-dependent complication in the oral cavity and gastrointestinal tract. Mucositis can cause a considerably reduced quality of life in cancer patients already suffering from physical and psychological exhaustion. However, the role of melatonin in the treatment of mucositis has recently been investigated, and offers an effective alternative therapy in the prevention and/or management of radio and/or chemotherapy-induced mucositis. This review focuses on the pathobiology and management of mucositis in order to improve the quality of cancer patients' lives.
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页数：20
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