Osteopontin in Cardiovascular Disease A Potential Therapeutic Target

被引：80
作者：
Waller, Alfonso H. [1 ]
Sanchez-Ross, Monica [1 ]
Kaluski, Edo [1 ]
Klapholz, Marc [1 ]
机构：
[1] UMDNJ, New Jersey Med Sch, Div Cardiol, Dept Med, Newark, NJ 07103 USA
来源：
CARDIOLOGY IN REVIEW | 2010年 / 18卷 / 03期
关键词：
osteopontin; myocardial infarction; heart failure; calcification; valvular disease; myocardial remodeling; MICROVASCULAR ENDOTHELIAL-CELLS; LEFT-VENTRICULAR DILATION; ANGIOTENSIN-II; PLASMA OSTEOPONTIN; MYOCARDIAL-INFARCTION; MESSENGER-RNA; ATHEROSCLEROTIC LESIONS; BONE SIALOPROTEIN; CARDIAC FIBROSIS; HEART-FAILURE;
D O I：
10.1097/CRD.0b013e3181cfb646
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Osteopontin (OPN), also known as 44kDa bone phosphoprotein, sialoprotein I, secreted phosphoprotein I, 2ar, uropontin, and early T-lymphocyte activation-1 (Eta-1), is a multifunctional protein. OPN has been found to be expressed in various cell types and species with many physiologic and pathologic functions. OPN has emerged as a potential biomarker and mediator in cardiovascular disease. In this review, we will discuss the roles of OPN in cardiovascular disease, specifically in vascular and valvular heart disease, myocardial infarction and heart failure.
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收藏
页码：125 / 131
页数：7
相关论文
共 68 条
  • [1] Clinical and echocardiographic correlates of plasma osteopontin in the community:: the Framingham Heart Study
    Arnlov, J.
    Evans, J. C.
    Benjamin, E. J.
    Larson, M. G.
    Levy, D.
    Sutherland, P.
    Siwik, D. A.
    Wang, T. J.
    Colucci, W. S.
    Vasan, R. S.
    [J]. HEART, 2006, 92 (10) : 1514 - 1515
  • [2] Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction
    Ashizawa, N
    Graf, K
    Do, YS
    Nunohiro, T
    Giachelli, CM
    Meehan, WP
    Tuan, TL
    Hsueh, WA
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (10) : 2218 - 2227
  • [3] Eta-1 (osteopontin): An early component of type-1 (cell-mediated) immunity
    Ashkar, S
    Weber, GF
    Panoutsakopoulou, V
    Sanchirico, ME
    Jansson, M
    Zawaideh, S
    Rittling, SR
    Denhardt, DT
    Glimcher, MJ
    Cantor, H
    [J]. SCIENCE, 2000, 287 (5454) : 860 - 864
  • [4] Identification of dual α4β1 integrin binding sites within a 38 amino acid domain in the N-terminal thrombin fragment of human osteopontin
    Bayless, KJ
    Davis, GE
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (16) : 13483 - 13489
  • [5] Bayless KJ, 1998, J CELL SCI, V111, P1165
  • [6] BEADENKOPF WG, 1964, AMER J ROENTGENOL RA, V92, P865
  • [7] Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice
    Bruemmer, D
    Collins, AR
    Noh, G
    Wang, W
    Territo, M
    Arias-Magallona, S
    Fishbein, MC
    Blaschke, F
    Kintscher, U
    Graf, K
    Law, RE
    Hsueh, WA
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (09) : 1318 - 1331
  • [8] Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression
    Chellaiah, MA
    Kizer, N
    Biswas, R
    Alvarez, U
    Strauss-Schoenberger, J
    Rifas, L
    Rittling, SR
    Denhardt, DT
    Hruska, KA
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (01) : 173 - 189
  • [9] Cardiac remodeling-concepts and clinical implications: A consensus paper from an international forum on cardiac remodeling
    Cohn, JN
    Ferrari, R
    Sharpe, N
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 35 (03) : 569 - 582
  • [10] Osteopontin modulates angiotensin II-induced fibrosis in the intact murine heart
    Collins, AR
    Schnee, J
    Wang, W
    Kim, S
    Fishbein, MC
    Bruemmer, D
    Law, RE
    Nicholas, S
    Ross, RS
    Hsueh, WA
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (09) : 1698 - 1705
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