Synthesis of 2′,3′-dideoxy-3′-fluoro-L-ribonucleosides as potential antiviral agents from D-sorbitol

被引：22

作者：

Chun, BK

Schinazi, RF

Cheng, YC

Chu, CK ^{[1
]}

机构：

[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

[2] Emory Univ, Sch Med, Vet Affairs Med Ctr, Decatur, GA 30033 USA

[3] Yale Univ, Sch Med, New Haven, CT 06510 USA

来源：

CARBOHYDRATE RESEARCH | 2000年 / 328卷 / 01期

关键词：

D-sorbitol; 2; 3; '-dideoxy-3; '-fluoro-L-ribonucleosides; 3 '-deoxy-3 '-fluoro-D-thymidine (FLT);

D O I：

10.1016/S0008-6215(99)00312-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2',3'-Dideoxy-3'-fluoro-L-ribonucleosides were synthesized as potential antiviral agents. The key intermediate, methyl 5-O-benzoyl-2,3-dideoxy-3-fluoro-L-ribofuranoside, which was prepared from D-sorbitol, was condensed with pyrimidine and purine bases to obtain the respective nucleosides. Among them, the cytosine analogue 2',3'-dideoxy-3'-fluoro-alpha-L-cytidine showed a moderate anti-HBV activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：49 / 59

页数：11

共 3 条

[1] Conformational polymorphism of D-sorbitol (D-glucitol):: the crystal and molecular structures of D-glucitol 2/3-hydrate and epsilon D-glucitol
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