Lipid autoreactivity in multiple sclerosis

被引：12

作者：

Blewett, M. M. ^{[1
]}

机构：

[1] Harvard Univ, Cambridge, MA 02138 USA

来源：

MEDICAL HYPOTHESES | 2010年 / 74卷 / 03期

关键词：

MYELIN BASIC-PROTEIN; EPSTEIN-BARR-VIRUS; KILLER T-CELLS; BORRELIA-BURGDORFERI ANTIBODIES; EBV-ASSOCIATED MONONUCLEOSIS; TYPE-1; DIABETES-MELLITUS; TERM GLOBAL DEFICIT; BLOOD-BRAIN-BARRIER; OF-THE-LITERATURE; PROTEOLIPID PROTEIN;

D O I：

10.1016/j.mehy.2009.10.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Lipids comprise over 70% of the myelin sheath but have been largely underinvestigated as autoantigens in multiple sclerosis (MS). This paper cites evidence for the involvement of lipid autoreactivity in MS and details how self lipid cross-reactivity may also contribute to the development of type I diabetes and autoimmune thyroid disorders (both of which have been associated with MS). A further analysis of myelin chemistry suggests several mechanisms by which infection may contribute to etiology and trigger lipid autoreactivity via molecular mimicry. This analysis may aid the development of new therapies for autoimmune diseases. (C) 2009 Elsevier Ltd. All rights reserved.

引用

收藏

页码：433 / 442

页数：10

相关论文

共 154 条

[1] Human herpesvirus-6 (HHV-6) infection in multiple sclerosis: a preliminary report [J].

Ablashi, DV ;

Lapps, W ;

Kaplan, M ;

Whitman, JE ;

Richert, JR ;

Pearson, GR .

MULTIPLE SCLEROSIS, 1998, 4 (06) :490-496

[2] Mechanisms of disease: Molecular mimicry and autoimmunity. [J].

Albert, LJ ;

Inman, RD .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (27) :2068-2074

[3] T-CELLS RESPONSIVE TO MYELIN BASIC-PROTEIN IN PATIENTS WITH MULTIPLE-SCLEROSIS [J].

ALLEGRETTA, M ;

NICKLAS, JA ;

SRIRAM, S ;

ALBERTINI, RJ .

SCIENCE, 1990, 247 (4943) :718-721

[4] Antibiotic use and risk of multiple sclerosis [J].

Alonso, Alvaro ;

Jick, Susan S. ;

Jick, Hershel ;

Hernan, Miguel A. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2006, 163 (11) :997-1002

[5] Patients with insulin-dependent diabetes but not those with non-insulin-dependent diabetes have anti-sulfatide antibodies as determined with a new ELISA assay [J].

Andersson, K ;

Buschard, K ;

Fredman, P ;

Kaas, A ;

Lidström, AM ;

Madsbad, S ;

Mortensen, H ;

Månsson, JE .

AUTOIMMUNITY, 2002, 35 (07) :463-468

[6] A glycan shield for bacterial sphingolipids [J].

Arora, Pooja ;

Porcelli, Steven A. .

CHEMISTRY & BIOLOGY, 2008, 15 (07) :642-644

[7] Epstein-Barr virus antibodies and risk of multiple sclerosis -: A prospective study [J].

Ascherio, A ;

Munger, KL ;

Lennette, ET ;

Spiegelman, D ;

Hernán, MA ;

Olek, MJ ;

Hankinson, SE ;

Hunter, DJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (24) :3083-3088

[8] Interlaboratory comparison of test results for detection of Lyme disease by 516 participants in the Wisconsin State Laboratory of Hygiene College of American Pathologists proficiency testing program [J].

Bakken, LL ;

Callister, SM ;

Wand, PJ ;

Schell, RF .

JOURNAL OF CLINICAL MICROBIOLOGY, 1997, 35 (03) :537-543

[9] REVERSIBLE INHIBITION OF OLIGODENDROCYTE PROGENITOR DIFFERENTIATION BY A MONOCLONAL-ANTIBODY AGAINST SURFACE GALACTOLIPIDS [J].

BANSAL, R ;

PFEIFFER, SE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) :6181-6185

[10] CD1 antigen presentation: how it works [J].

Barral, Duarte C. ;

Brenner, Michael B. .

NATURE REVIEWS IMMUNOLOGY, 2007, 7 (12) :929-941

← 1 2 3 4 5 6 7 8 9 10 →