Pleiotropic Effects of Statin in Therapy in Heart Failure: A Review

被引：13
作者：
Correale, Michele [1 ]
Abruzzese, Silvia [1 ]
Greco, Carmen A. [1 ]
Concilio, Morena [1 ]
Di Biase, Matteo [1 ]
Brunetti, Natale D. [1 ]
机构：
[1] Univ Foggia, Dept Cardiol, I-71100 Foggia, Italy
来源：
CURRENT VASCULAR PHARMACOLOGY | 2014年 / 12卷 / 06期
关键词：
Statins; heart failure; LEFT-VENTRICULAR FUNCTION; IMPROVES CARDIAC-FUNCTION; NITRIC-OXIDE SYNTHASE; SCANDINAVIAN-SIMVASTATIN-SURVIVAL; CLINICAL-TRIALS UPDATE; ATORVASTATIN THERAPY; DIASTOLIC DYSFUNCTION; REDUCTASE INHIBITORS; PLATELET ACTIVATION; CORONARY EVENTS;
D O I：
10.2174/1570161112999141127161508
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Clinical trials demonstrated that statin therapy is associated with a significant reduction in cardiovascular morbidity and mortality when used for either primary or secondary prevention of cardiovascular events. Several studies have shown that statins, having an important effect in the prevention of acute coronary syndromes, are also able to prevent heart failure (HF) in patients with coronary artery disease. This review summarizes the experimental and clinical evidence regarding the role of statins in the management of HF.
引用
收藏
页码：873 / 884
页数：12
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